“…Similar analysis of the standardmaterials used to fix the specimens failed to show detectable quantities of lead and therefore established that the lead was associated with the tissue. These data show that in this case the lead levels in nerve, muscle, and spinal cord were comparable in magnitude to those found in similar tissues many years ago in a particular case of lead paralysis (Herter, 1895 Lead in ALS and control groups A lead content (,ug/g dry weight) of 17-7 and 21-2 in heart and skeletal muscle, respectively, is much higher than the recently reported values of 0-26-0-30 in either muscle for a large series of necropsies not involving ALS or known exposure to lead (Barry and Mossman, 1970;Soman et al, 1970). This observation combined with the need for more data on the lead content of spinal cord and nerve tissue suggested measurements by emission spectrography of the lead present in nerve, cervical segment of spinal cord, and skeletal muscle tissue in two series-one involving ALS (ALS group), and another not involving either ALS or known lead exposure (control group).…”