Studies on lysosomes—X

Constituents of Mammea americana L. XII: Biological Data for Xanthones and Benzophenones

“…Two sets of isomeric xanthones, 2-and 4-hydroxyxanthones (111 and VI) and 1,s-and 1,7-dihydroxyxanthones (IX and XI), were subsequently isolated from this polar extract.Their structures were dekrmined by comparison with synthetic materials(2)(3)(4). when assayed against S-180 tumor cells grown in stationary cell culture.…”

Engineering Nanoparticles toward the Modulation of Emerging Cancer Immunotherapy

“…In 1968, liposomes were first described as small artificial spherical vesicles made from naturally occurring nontoxic phospholipids and cholesterol. [ 114 ] These phospholipid bubbles with a bilayer membrane structure serve as promising systems for drug delivery due to their ultrasmall size, easy‐manufacture, hydrophobicity, and polydispersity. The first FDA‐approved nanodrug, Doxil, was based on PEGylated nanoliposomes for the stable loading and sustained release of Dox, [ 115 ] which fully demonstrated that liposomes had excellent compatibility, safety, and metabolism in vivo.…”

Role of analytical chemistry in carcinogenesis studies

“…On replication of such a substituted DNA a wrong base niay be incorporated producing a somatic mutation. The promoting agent niay act by permitting the mutation to be expressed (15). The major portion of the genetic information is covered by a curtain of repressive histones so that errors behind the curtain do not do harm until they are permitted to see the light of day.…”

“…Vnfortunately, this kind of thesis does not lead to a generalization useful to the analytical chemist, hut does provide the enzymologist Lyith some clues. Thus, the capability to liberate lysosomal enzymes from a preparation of rabbit liver lysosomes has become the first independent guide post for assessing promoting activity of suspected chemical offenders (15). This technique needs to be expanded until it can replace the more laborious mouse skin test.…”