Studies on Lymphocytes. II. The Production of Lymphocytosis by Intravenous Heparin in Calves

Jansen, C. R.; Cronkite, Eugene P.; Mather, George C.; Nielsen, Niels O.; Rai, Kanti; Adamik, Emil R.; Sipe, C. R.

doi:10.1182/blood.v20.4.443.443

Cited by 46 publications

(8 citation statements)

References 6 publications

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“…Bradfield & Born (1969), however, observed a lymphocytosis in the rat caused by an inhibition of emigration from the blood. Heparin induced a lymphocytosis and an increase in thoracic duct output of lymphocytes in the calf (Jansen et al, 1962) indicating an increased emigration of lymphocytes from lymph nodes. Gowans & Knight (1964) could not demonstrate an effect of heparin in recirculation studies in the rat.…”

Section: Eflect Of Heparin On Lymphocyte Recirculationmentioning

confidence: 94%

The Predominant Role of the Spleen in Lymphocyte Recirculation

Pabst

Trepel

1975

Cell Proliferation

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Lymphocyte recirculation through the isolated pig spleen was studied by means of a perfusion system which kept the organ alive for a prolonged period of time. By changing the perfusate to a leucocyte‐enriched or cell‐free perfusate and taking serial arterial and venous samples, the numbers of lymphocytes which homed to or were released from the spleen were measured. In all experiments more lymphocytes homed than were released per minute. There was no apparent difference when autologous or allogeneic cells were used. The number of lymphocytes released depended on the number of lymphocytes homed previously. During the phase of constant release up to 3‐3 × 106 lymphocytes were released per gram spleen per minute. From these values it can be extrapolated that up to 270 × 109 lymphocytes recirculate through the isolated pig spleen per day. Based on kinetic data from other species it is estimated that in the entire pig a total number of 300–400 × 109 lymphocytes recirculate per day. Thus, it can be concluded that the spleen is the most important organ for lymphocyte recirculation in the pig.

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Section: Eflect Of Heparin On Lymphocyte Recirculationmentioning

confidence: 94%

The Predominant Role of the Spleen in Lymphocyte Recirculation

Pabst

Trepel

1975

Cell Proliferation

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“…This enables them to complex with and change the properties of plasma proteins and more than 50 identified enzymes. 20 Jansen et al 21 have described lymphocytosis in calves after an intravenous injection of heparin. In rodents heparin and other mucopolysaccharides have an inhibitory effect on the shift of lymphocytes from blood to lymph nodes which results in an increase in the level of circulating lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Prophylaxis of Migraine with Anionic Polyelectrolytes

Thonnard-Neumann

Bigelow

1988

Headache

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SYNOPSIS In previous studies on patients with migraine headaches we found that 50% had reduced concentrations of basophils and lymphocytes. Treatment with inhalations of heparin often restored these blood indices to normal and was accompanied by a reduction in migraine headache, We report here data on the long term treatment of 37 migraine patients with inhalations of heparin and with an oral semi‐synthetic heparinoid, Pentosan Polysulfate (PNP). 27 patients responded with a mean improvement in migraine index of 79% and as a group showed significant increases in basophil, total lymphocyte, and in particular T‐cell concentrations. Ten patients whose migraine headaches were related to their menstrual cycles were relatively unresponsive to heparin or PNP. They had a general leukopenia, but basophils were within normal range.

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“…Figure 2 is a detailed chart of the lym-phocyte concentration in patient 11. The lymphocytosis observed during the first hours of the ECI sessions was due to the heparinization (Jansen et al 1962) and appeared also when heparin alone was given.…”

Section: Patient No Sex Age (Yrs) T a B L E I Data On The 4 Patientsmentioning

confidence: 98%

Studies on Lymphocytes during Extracorporeal Irradiation of the Blood in Patients with Active Cirrhosis

Andersen

Bjerrum

Ranek

1970

Scandinavian Journal of Haematology

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The lymphocyte concentration in the blood was followed closely in four patients with active cirrhosis who were treated with extracorporeal irradiation of the blood (ECI). A reduction to 25 96 of the original values was obtained, and three months after treatment the lymphocyte concentration remained below 50 % of pretreatment values. This is not significantly different from the results previously obtained in uraemic patients although a much more concentrated treatment schedule was employed in the present patients. This shows that the large majority of the recirculating lymphocytes pass through the blood within 3 4 days. In vitro stimulation of blood lymphocytes with phytohaemagglutinin showed that in the three patients studied the response per cell did not change significantly during ECI. However, the initially positive transformation response to tuberculin in vitro changed into a negative one during ECI in all cases, indicating that a selective depletion of the tuberculin-sensitive cells of the blood took place during ECI.

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Studies on Lymphocytes. II. The Production of Lymphocytosis by Intravenous Heparin in Calves

Cited by 46 publications

References 6 publications

The Predominant Role of the Spleen in Lymphocyte Recirculation

The Predominant Role of the Spleen in Lymphocyte Recirculation

Prophylaxis of Migraine with Anionic Polyelectrolytes

Studies on Lymphocytes during Extracorporeal Irradiation of the Blood in Patients with Active Cirrhosis

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