Studies on lipid peroxidation in rat tissues following administration of low and moderate doses of cadmium chloride

Manca, D.; Ricard, Anne C.; Trottier, Bertin; Chevalier, Gaston

doi:10.1016/0300-483x(91)90030-5

Cited by 285 publications

(136 citation statements)

References 37 publications

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“…The present results have clearly demonstrated the ability of Cd to induce oxidative stress in rat plasma and RBC as evidenced by increased lipid peroxidation after 20 days of Cd treatment. This finding is in agreement with several reports demonstrating that Cd induces oxidative stress in tissues by increasing lipid peroxidation and by altering the antioxidant status in several tissues (4)(5)(6)25).…”

Section: Discussionsupporting

confidence: 93%

“…The molecular mechanisms of its toxicity are not yet well defined. Cd has been demonstrated to stimulate free radical production, resulting in oxidative deterioration of lipids, proteins and DNA, and initiating various pathological conditions in humans and animals (4,7). After the intake and resorption, Cd enters the blood where it binds to the red blood cell (RBC) membranes and plasma albumin (8).…”

Section: Introductionmentioning

confidence: 99%

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Vitamin E protects against oxidative damage caused by cadmium in the blood of rats

et al. 2009

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Vitamin E protects against oxidative damage caused by cadmium in the blood of rats

et al. 2009

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“…Lipoperoxide generation was markedly more elevated in pairs of Nile tilapia exposed to cadmium than in control (Table 2). Other studies have reported that lipid peroxidation is a consequence of cadmium exposure in both fish and mammals (Manca et al, 1991;Oner et al, 1994;Novelli et al, 1999). Lipoperoxide formation was increased by cadmium exposure, independent of social status.…”

Section: Discussionmentioning

confidence: 95%

“…As a non-degradable cumulative pollutant, cadmium can alter trophic levels for centuries, and freshwater Nile tilapia is particularly vulnerable to its exposure (Almeida et al, 2001). Although free radicalmediated cellular damage and ROS may contribute to cadmium's mechanism of toxicity (Manca et al, 1991;Novelli Filho et al, 2000), there is little information on the effect of cadmium exposure on markers of oxidative stress in social fish. In the present study, we observed that cadmium decreased aggression and growth in Nile tilapia.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress biomarkers and aggressive behavior in fish exposed to aquatic cadmium contamination

et al. 2009

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The objective of this study was to investigate the possible link between cadmium exposure, hepatic markers of oxidative stress and aggressive behavior in Nile tilapia (Oreochromis niloticus). Fish were first exposed to 0.75 mg/L CdCl 2 for 15 days (12 isolated fish for each group) and afterward a behavioral test was performed. Fish from the control and cadmium-exposed groups were paired for 1 h (6 pairs of fish per group) for determination of aggressiveness parameters. Immediately after the behavioral test, the animals were sacrificed and the liver was used to determine biochemical parameters. Cadmium decreased aggression in Nile tilapia. Subordinate animals exposed to cadmium showed decreased glutathione peroxidase (GSH-Px) activity compared to dominant ones. No alterations were observed in selenium-dependent glutathione peroxidase Se-GSH-P and Cu-Zn superoxide dismutase activities, but total superoxide dismutase activity was increased in subordinate animals exposed to cadmium compared to subordinate control. Catalase activity was increased in cadmium-exposed fish. Lipoperoxide concentrations also increased in cadmium exposed fish indicating that cadmium toxicity may affect oxidative stress biomarkers in Nile tilapia. Social stress induced lipoperoxidation in Nile tilapia, and subordinate animals exposed to cadmium responded with lower activities of liver antioxidant enzymes compared to dominant fish. The present study shows that cadmium exposure is capable of inducing changes in the social status and oxidative stress parameters in this species.O objetivo deste estudo foi investigar a possível relação entre a exposição ao cádmio, os marcadores hepáticos de estresse oxidativo e o comportamento agressivo em tilápia do Nilo (Oreochromis niloticus). Os peixes foram primeiramente expostos à concentração de 0,75 mg/L de CdCl 2 durante 15 dias (12 peixes isolados em cada grupo), após o qual o teste de comportamento foi aplicado. Peixes do grupo controle e do grupo exposto ao cádmio foram pareados durante 1 hora (6 pares de peixes por grupo) para determinação de parâmetros de agressividade. Imediatamente após o teste comportamental, os animais foram sacrificados e o fígado foi coletado para as determinações bioquímicas. O cádmio diminuiu a agressão em tilápias do Nilo. Animais subordinados e expostos ao cádmio mostraram uma redução na atividade da enzima glutationa peroxidase (GSH-Px), quando comparados aos dominantes. Nenhuma alteração foi observada na atividade da glutationa peroxidase dependente de selênio (Se-GSH-P) e na superóxido dismutase Cu Zn, mas a atividade total da superóxido dismutase aumentou em animais subordinados e expostos ao cádmio, quando comparado ao controle subordinado. A atividade da catalase aumentou em peixes expostos ao cádmio. As concentrações de lipoperóxido aumentaram em peixes expostos ao cádmio, indicando que a toxicidade deste pode afetar os biomarcadores de estresse oxidativo em tilápias do Nilo. O estresse social induziu lipoperoxidação em tilápia do Nilo e animais subordinados e expo...

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“…On the other hand, the Cd exposure has been shown to stimulate free radical production, resulting in various pathological conditions in humans and animals (El-Demerdash et al, 2004;Shaikh et al, 1999). Acute or chronic exposure of Cd has been associated with increased lipid peroxidation in testes, erythrocytes, and other soft tissues (Manca et al, 1991;Sarkar et al, 1997). Free-radicals can originate from exposure to cadmium, resulting in elevated chromosomal aberrations and declined mitotic index.…”

Section: Discussionmentioning

confidence: 99%

The protective role of honey against cytotoxicity of cadmium chloride in mice

Shahrour¹,

Zowail²,

Sharafeldin³

2016

Afr. J. Biotechnol.

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The present study aimed to investigate the honey (HY) protective role in opposition to cadmium (Cd) induced chromosomal aberrations of bone marrow and sperm abnormalities. Forty five (45) adult male albino mice were caged into six groups. Mice were injected, i.p, 300 mg HY/kg and/or 0.67 mg CdCl 2 /kg b.w for 96 h, separately and alternated. The alternated trials were continued for consecutive eight days. Results show that mice injected with cadmium had significant increase in the frequency of aberrant chromosomes as fragment, centric fusion, gap, stickiness and aneuploidy and in sperm abnormality. The administration of HY improved the frequency of the chromosomal aberrations and sperm abnormality induced by Cd.

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Studies on lipid peroxidation in rat tissues following administration of low and moderate doses of cadmium chloride

Cited by 285 publications

References 37 publications

Vitamin E protects against oxidative damage caused by cadmium in the blood of rats

Vitamin E protects against oxidative damage caused by cadmium in the blood of rats

Oxidative stress biomarkers and aggressive behavior in fish exposed to aquatic cadmium contamination

The protective role of honey against cytotoxicity of cadmium chloride in mice

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