Studies on Isotope Ratio Measurement of Cl by Inductively Coupled Plasma Triple-quad Mass Spectrometry

Abstract

isotope abundance measurements in nuclear chemistry 7,8,10 and the accurate determination by IDMS, [23][24][25][26][27][28][29] which require the precision of ca.

Inductively Coupled Plasma-Mass Spectrometry

“…5 They revealed the similar analytical performance of 265 nm femtosecond laser and 213 nm nanosecond laser ablation systems for Pb isotope ratio measurements of solder. They also reported on "Studies on Isotope Ratio Measurement of Cl by Inductively Coupled Plasma Triple-quad Mass Spectrometry", describing an isotope ratio measurement of Cl using ICP-MS/ MS. 6 Similar sensitivities as those obtained by ICP-SFMS and the precisions of 0.2 -0.5% of RSD at the concentration range of 1 -10 mg kg -1 were obtained. Speciation analysis is another important subject for ICP-MS applications.…”

“…1) enables us to remove interferences without any special sample preparation. 6,12 As well as ICP-MS/MS, single particle ICP-MS has been intensively investigated in recent years. …”

Universal N2O Reaction Gas To Remove Spectral Interferences of Nonmetallic Impurity Elements by Inductively Coupled Plasma Tandem Mass Spectrometry Analysis of High-Purity Magnesium Alloys

“…P + and Cl + can react with H 2 via the H-atom transfer reaction, generating PH 2 + and H 2 Cl + , whose signals are well separated from those of the interfering ions. 24,46 Except for the sensitivity to Si, which was slightly higher, the sensitivities to P and Cl in the H 2 reaction mode were both lower and the LODs of Si, P, and Cl were all higher than those in the N 2 O reaction mode. These results indicate that using only O 2 or H 2 as reaction gas cannot meet the demand of simultaneous determination of Si, P, S, and Cl; and using O 2 or H 2 individually as reaction gas to determine Si, P, S, and Cl is less sensitive than using N 2 O as reaction gas.…”

Purity determination of synthetic glucagon using a mass balance approach

“…Isotope dilution mass spectrometry (IDMS) was used to quantify the peptide impurities in our sample. IDMS is suitable as a definitive method because it does not depend on the sample recovery, has high precision, and can be tested for bias and unknown interferences 8 . IDMS methods involve adding a labeled version of the analyte as an internal standard to the sample, followed by sample processing and subsequent measurement of the peak area ratio of unlabeled to labeled analyte by LC-MS. IDMS is recognized as a primary method [9][10][11] and has been widely used to establish reference measurement procedures for biomarkers such as creatinine [12][13][14] , glucose [15][16][17] , cholesterol [18][19][20] , urea 21,22 , uric acid 23,24 and triglycerides 8,25 .…”