During rocket flights, ionized exhaust plumes from solid rocket motors may interfere with radio frequency (RF) transmission under certain conditions. To clarify the physical process involved and to establish the estimation methodology, a plume-RF interference experiment during a sea-level static firing test of a full-scale solid rocket motor was conducted. The result of the ground experiment was adequately matched by a computational fluid dynamics (CFD) model of the plume flow field coupled to a finite-difference timedomain (FDTD) model of RF transmission. The CFD/FDTD coupling method was then refined for predicting interference and RF attenuation levels during an actual rocket flight. The calculated far-field received levels were compared with the in-flight attenuation data at different look angles (angles between the vehicle axis and the line-of-sight of the antennas). The calculated results showed good agreement with the flight data over a wide range of look angles. An adaptation of the model, based on the diffraction theory, proved appropriate both for rough estimation of attenuation and for conducting a preliminary analysis of signal/rocket plume interactions. Nomenclature A = pre-exponential factor for Arrhenius expression, consistent unit c = speed of light, m/s d = width of plasma slab, m e = elementary charge, C E = electric field vector, V/m E a = activation energy for Arrhenius expression, J/mol E y = y-component of electric field, V/m H = magnetic field vector, V/m k = rate coefficient, (m 3 /mol) N−1 /s k B = Boltzmann constant, J/K m e = electron mass, kg n = time step for FDTD method N = reaction order N h = heavy-particle number density, m −3 2 N e = electron number density, m −3 P c = combustion chamber pressure, Pa Q e = electron collision cross section, m 2 R = universal gas constant, J/K/mol T = flow temperature, K T e = electron temperature, K V = received radio wave voltage with motor plume, V V 0 = received radio wave voltage without motor plume, V α = look angle of launch vehicle, deg (shown in Fig. 1) β = roll angle of launch vehicle, deg (shown in Fig. B1) χ = index of attenuation χ 0 = relative electric susceptibility ∆t = time step used in FDTD method, s ∆x, ∆y, ∆z = grid sizes in x, y and z directions, respectively, used in FDTD method, m Φ Φ Φ Φ = recursive accumulator, C/m 2 ε = relative permittivity of free electron ε 0 = vacuum permittivity, F/m η = temperature exponent for Arrhenius expression ϕ c = critical angle, rad λ = radio wave wavelength, m µ = index of refraction ν e = electron collision frequency, s −1 ω = radio wave angular frequency, s −1 ω p = electron plasma frequency, s −1