Studies on Inhibitors of Skin-Tumor Promotion. Inhibitory Effects of Triterpenes from Cochlospermum tinctorium on Epstein-Barr Virus Activation

Diallo, Bilo; Vanhaelen, Maurice; Vanhaelen-Fastré, Renée; Konoshima, Takao; Kozuka, Mutsuo; Tokuda, Harukuni

doi:10.1021/np50064a039

Cited by 61 publications

(31 citation statements)

References 8 publications

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“…9). AA has been shown to induce tumour growth inhibition [36], although the exact pathway is still unclear. If the agonist (here AA) itself is considered as an antitumour agent, it is highly unlikely that it would diminish doxorubicin's antitumour effect.…”

Section: Anti-apoptotic Signalling Mechanismsmentioning

confidence: 99%

The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis

et al. 2011

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Section: Anti-apoptotic Signalling Mechanismsmentioning

confidence: 99%

The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis

et al. 2011

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“…A investigação química de plantas do gênero tem resultado no isolamento de metabólitos secundári-os pertencentes a várias classes estruturais como flavonóides, apocarotenóides, acetogeninas, triacilbenzenos, triterpenos e esteróides 4,[7][8][9][10][11] .…”

Section: Introductionunclassified

Constituintes químicos voláteis e não-voláteis de Cochlospermum vitifolium (Willdenow) Sprengel

et al. 2005

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Recebido em 3/2/04; aceito em 5/7/04; publicado na web em 5/11/04 VOLATILE AND NON-VOLATILE CHEMICAL CONSTITUENTS OF Cochlospermum vitifolium (WILLDENOW) SPRENGEL. The essential oils from leaves, root bark and root wood of Cochlospermum vitifolium were investigated for the first time. The oils were obtained by hydrodistillation and analyzed by GC/MS. The main volatile constituents were β-caryophyllene (8.2 -46.5%), β-bisabolene (11.5 -29.3%), γ-muurolene (28.4%), α-humulene (26.0%), 1-hydroxy-3-hexadecanone (16.2 -19.5%) and β-pinene (10.6%). Phytochemical analysis of the root bark and root wood extracts yielded excelsin, pinoresinol, narigenin, aromadendrin, galic acid and a triacylbenzene, along with β-sitosterol and stigmasterol and their D-glucosides. The structures of all compounds were determined by analyses of the spectroscopic data (NMR and MS), and comparison with the literature.Keywords: Cochlospermum vitifolium; Cochlospermaceae; chemical composition. INTRODUÇÃOA família Cochlospermaceae compreende apenas dois gêneros, Cochlospermum e Amoreuxia, os quais reúnem cerca de quinze espécies distribuídas principalmente nas regiões tropicais do globo terrestre, especialmente nas Américas e África. A principal diferença entre os dois taxons encontra-se na simetria da flor, a qual é actinomórfica em Cochlospermum e zigomórfica em Amoreuxia 1 .O gênero Cochlospermum, de distribuição pantropical, é constituído por aproximadamente onze espécies, quatro das quais, C. angolense, C. planchonii, C. tinctorium e C. vitifolium, apresentam significante importância medicinal [1][2][3][4][5][6] . A investigação química de plantas do gênero tem resultado no isolamento de metabólitos secundári-os pertencentes a várias classes estruturais como flavonóides, apocarotenóides, acetogeninas, triacilbenzenos, triterpenos e esteróides 4,7-11 .A ocorrência freqüente de C. vitifolium, aliada à ausência de estudos químicos, exceto por um trabalho que relata o isolamento de dois apocarotenóides 12 , motivou-nos a investigar a constituição quí-mica da referida espécie. C. vitifolium é uma pequena árvore, popularmente conhecida como algodão-bravo ou algodão do campo em diversos estados do país, e como pacotê, no Ceará. Floresce no perí-odo em que as folhas caem, de dezembro a março, no hemisfério Norte, e de junho a outubro, abaixo da linha do equador 1 . No estado do Ceará, a época de floração coincide com o período de total estiagem, quando a paisagem se apresenta completamente árida. Neste cenário, C. vitifolium encontra-se totalmente despida de folhagem, entretanto, suas flores grandes e vistosas, em cachos terminais de coloração amarelo-dourado, enfeitam os sertões cearenses. Em diversos países, como Cuba, Costa Rica, Guatemala e México, a referida espécie é de importância etnofarmacológica, sendo utilizada principalmente no tratamento de malária, icterícia, úlcera e doenças renais, hepáticas e respiratórias, além de possuir propriedades emenagogas 5 .Este trabalho descreve os resultados obtidos na investigação quí-mica de C. vitifo...

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“…[7][8][9] Triterpene arjunolic acid (5) was previously isolated from other plants of the genus Myrtaceae, including Eugenia florida 10 and Melaleuca alternifolia, 11 and a few biological properties are cited in the literature. [12][13][14][15][16] Table 1 shows the results of analgesic activity of extract and fractions from M. tomentosa (leaves and branches) against the writhing test, administered intraperitoneally, at 10 mg/kg, which indicates that some of them exhibit pronounced effects. The most promising result was demonstrated by dichloromethane fraction, which caused inhibition of 91.1 ± 3.2%, whereas the reference drugs acetyl salicylic acid and indomethacin, caused inhibition of just 18.0 ± 4.0 and 45.7 ± 2.0%, respectively, in the same model and dose.…”

Section: Resultsmentioning

confidence: 99%

Chemical composition and analgesic activity of the leaves and branches of Marlierea tomentosa Camb.

Messias¹,

Buzzi²,

Fischer³

et al. 2008

Quím. Nova

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ChemiCal Composition and analgesiC aCtivity of the leaves and branChes ofThis paper describes the isolation of five phytoconstituents from Marlierea tomentosa. The triterpenes α-amyrin (1) and β-amyrin (2), and the flavonoids quercitrin (3) and isoquercetin (4), were isolated from the leaves. The branches afforded the triterpene arjunolic acid (5). The antinociceptive activity of crude extract, fractions and compound 5 were tested using the writhing and formalin tests in mice. The crude extract, some fractions, particularly dichloromethane and butanol (leaves), ethyl acetate (branches) and arjunolic acid (5) (81.2% inhibition) were more active against the writhing test than the two reference drugs, acetylsalicylic acid and indomethacin.

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Studies on Inhibitors of Skin-Tumor Promotion. Inhibitory Effects of Triterpenes from Cochlospermum tinctorium on Epstein-Barr Virus Activation

Cited by 61 publications

References 8 publications

The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis

The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis

Constituintes químicos voláteis e não-voláteis de Cochlospermum vitifolium (Willdenow) Sprengel

Chemical composition and analgesic activity of the leaves and branches of Marlierea tomentosa Camb.

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