Studies on Inhibitors of Skin Tumor Promotion. XI. Inhibitory Effects of Flavonoides from Scutellaria baicalensis on Epstein-Barr Virus Activation and Their Anti-tumor-Promoting Activities.

Konoshima, Takao; Kokumai, Midori; Kozuka, Mutsuo; Iinuma, Munekazu; Mizuno, Mizuo; Tanaka, Toŝhiyuki; Tokuda, Harukuni; Nishino, Hoyoku; Iwashima, Akio

doi:10.1248/cpb.40.531

Cited by 51 publications

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“…Scutellaria baicalensis, known as Chinese skullcap and Huang Qin, contains several flavonoids and is a widely used herb in traditional Chinese medicine with antitumor, antiviral, antibacterial and anti-inflammatory properties (7)(8)(9)(10)(11). Baicalein and wogonin are flavonoid-like chemical compounds which are found in Scutellaria baicalensis and have been reported to inhibit cell growth and induce apoptosis in various tumors (12,13).…”

Section: Introductionmentioning

confidence: 99%

Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells

Kim

et al. 2012

Molecular Medicine Reports

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Abstract. The purpose of this study was to determine the effects of baicalein and wogonin, which are compounds derived from the Chinese herb Scutellaria baicalensis, in suppressing the viability of HT-29 human colon cancer cells. Following treatment with baicalein or wogonin, several apoptotic events were observed, including DNA fragmentation, chromatin condensation and increased cell cycle arrest in the G1 phase. Baicalein and wogonin decreased Bcl-2 expression, whereas the expression of Bax was increased in a dose-dependent manner compared with the control. Furthermore, the induction of apoptosis was accompanied by an inactivation of phosphatidylinositol 3-kinase (PI3K)/Akt in a dose-dependent manner. The administration of baicalein to mice resulted in the inhibition of the growth of HT-29 xenografts without any toxicity following 5 weeks of treatment. The results indicated that baicalein induced apoptosis via Akt activation in a p53-dependent manner in the HT-29 colon cancer cells and that it may serve as a chemopreventive or therapeutic agent for HT-29 colon cancer.

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Section: Introductionmentioning

confidence: 99%

Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells

Kim

et al. 2012

Molecular Medicine Reports

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“…Baicalein, a flavonoid derived from Scutellaria baicalensis, has been shown to have antiproliferative and lipooxygenase-inhibitory activity (Huang et al 1994). Other flavones from S. baicalensis have been shown to inhibit mouse skin tumor promotion in two-stage carcinogenesis testing (Konoshima et al 1992). Serenoa repens is a potent phytoestrogen, and an n-hexane lipid/sterol extract of S. repens has been shown to be an inhibitor of both type 1 and type 2 5␣-reductase, the enzyme that converts testosterone to dihydrotestosterone, the active androgen in the prostate (Iehle et al 1995).…”

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PC-SPES and Prostate Cancer

Geliebter

Mittelman

Tiwari

2001

The Journal of Nutrition

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“…Ohigashi et al (1992) screened marine algae, which is claimed to reduce cancer risk in Japan, for EBV-EA activation inhibitory activity and the dichloromethane of Undaria pinnatifida that showed strong inhibitory activity (>70% at 4 µg ml -1 ) was also found to completely suppress tumour formation on mouse skin induced by DMBA and TPA. The acetone extract of Scutellaria baicalensis that showed significant inhibitory effects on EBV-EA activation in vitro was fractionated with ethyl acetate and two flavones, 5,7,2′-trihydroxyflavone and 5,7,2′,3′-tetrahydroxyflavone were found to exhibit strong inhibitory effect on mouse skin tumour promotion in an in vivo two-stage carcinogenesis test (Konoshima et al, 1992).…”

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Anti-tumour promoter activity in Malaysian ginger rhizobia used in traditional medicine

1999

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Summary Zingiberaceae rhizomes commonly used in the Malaysian traditional medicine were screened for anti-tumour promoter activity using the short-term assay of inhibition of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) in Raji cells. The inhibition of TPA-induced EBV-EA was detected using the indirect immunofluorescence assay (IFA) and Western blot technique. The indirect IFA detected the expression/inhibition of EBV-EA-D (diffused EA antigen), whereas the Western blot technique detected the expression/inhibition of both EBV-EA-D and EA-R (restricted EA antigen). Seven rhizomes were found to possess inhibitory activity towards EBV activation, induced by TPA; they are: Curcuma domestica, C. xanthorrhiza, Kaempferia galanga, Zingiber cassumunar, Z. officinale, Z. officinale (red variety), and Z. zerumbet. A cytotoxicity assay was carried out to determine the toxicity of the Zingiberaceae rhizome extracts. The rhizome extracts that exhibited EBV activation inhibitory activity had no cytotoxicity effect in Raji cells. Therefore, the present study shows that several Zingiberaceae species used in Malaysian traditional medicine contain naturally occurring non-toxic compounds that inhibit the EBV activation, which, if further investigated, could contribute in the development of cancer prevention methods at the tumour-promoting stage.

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Studies on Inhibitors of Skin Tumor Promotion. XI. Inhibitory Effects of Flavonoides from Scutellaria baicalensis on Epstein-Barr Virus Activation and Their Anti-tumor-Promoting Activities.

Cited by 51 publications

References 0 publications

Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells

Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells

PC-SPES and Prostate Cancer

Anti-tumour promoter activity in Malaysian ginger rhizobia used in traditional medicine

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