Studies on Induced Reversions at the Arginine Locus of Aspergillus chevalieri (Mangin)

Nanda, Geeta; Nandi, Pinki; Mishra, A. K.

doi:10.1016/s0044-4057(75)80013-x

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Genetic characterization of formaldehyde-induced ad-3 mutants is in progress. Formaldehyde was found to induce point mutation by reverse-mutation in both Neurospora (60,61) and Aspergillus (62), but not in Salmonella (63,64 (65); (2) Interaction with OtherMutagens. In Drosophila, Sobels (69) found that either pre-or posttreatments with formaldehyde almost doubled the frequencies of x-ray-induced sex-linked recessive lethals.…”

Section: Formaldehydesolutions Early Experiments Inmentioning

confidence: 99%

Report of the Federal Panel on Formaldehyde

1982

Environmental Health Perspectives

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The Federal Panel on Formaldehyde concluded that definitive experiments exist which demonstrate the mutagenicity and carcinogenicity of formaldehyde under laboratory conditions. Formaldehyde induces both gene mutations and chromosomal aberrations in a variety of test systems. Inhalation of formaldehyde causes cancer of the nose in rats. The concentrations of formaldehyde in inhaled air that caused nasal cancer in Fisher 344 rats are within the same order of magnitude as those to which humans may be exposed. The data presently available do not permit a direct assessment of the carcinogenicity of formaldehyde to man. Epidemiologic studies on exposed human populations are in progress and may further clarify the situation. Other experimental and human studies on toxic effects such as teratogenicity and reproductive disorders are as yet inadequate for a health risk assessment.The CIIT 24 month study on animal carcinogenicity has not yet been completely evaluated. Additional data are expected on the effects of prolonged exposure to lower doses of formaldehyde and on the possible carcinogenicity of formaldehyde in the mouse. The panel recommends that, for a comprehensive health risk assessment, further experiments be conducted on the effects of other modes of exposure (ingestion and skin penetration), the effects in humans, and on the pharmacokinetics of formaldehyde in man and animals and the possible role for formaldehyde in reproductive and chronic respiratory disorders.It is the conclusion of the panel that formaldehyde should be presumed to pose a carcinogenic risk to humans.

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Section: Formaldehydesolutions Early Experiments Inmentioning

confidence: 99%

Report of the Federal Panel on Formaldehyde

1982

Environmental Health Perspectives

View full text Add to dashboard Cite

show abstract

“…Genetic characterization of formaldehyde-induced ad-3 mutants is in progress. Formaldehyde was found to induce point mutation by reverse-mutation in both Neurospora (60,61) and Aspergillus (62), but not in Salmonella (63, 64). The National Toxicology Program has reported that, in recent inves-Environmental Health Perspectives tigations by three independent laboratories using the Ames test, formaldehyde tested positively in one of four bacterial strains (TA 100) that detects base-pair substitution mutations.…”

Section: Genetic Effects Of Exposurementioning

confidence: 99%

Report of the Federal Panel on Formaldehyde.

1982

Environ Health Perspect

View full text Add to dashboard Cite

The Federal Panel on Formaldehyde concluded that definitive experiments exist which demonstrate the mutagenicity and carcinogenicity of formaldehyde under laboratory conditions. Formaldehyde induces both gene mutations and chromosomal aberrations in a variety of test systems. Inhalation of formaldehyde causes cancer of the nose in rats. The concentrations of formaldehyde in inhaled air that caused nasal cancer in Fisher 344 rats are within the same order of magnitude as those to which humans may be exposed. The data presently available do not permit a direct assessment of the carcinogenicity of formaldehyde to man. Epidemiologic studies on exposed human populations are in progress and may further clarify the situation. Other experimental and human studies on toxic effects such as teratogenicity and reproductive disorders are as yet inadequate for a health risk assessment. The CIIT 24 month study on animal carcinogenicity has not yet been completely evaluated. Additional data are expected on the effects of prolonged exposure to lower doses of formaldehyde and on the possible carcinogenicity of formaldehyde in the mouse. The panel recommends that, for a comprehensive health risk assessment, further experiments be conducted on the effects of other modes of exposure (ingestion and skin penetration), the effects in humans, and on the pharmacokinetics of formaldehyde in man and animals and the possible role for formaldehyde in reproductive and chronic respiratory disorders. It is the conclusion of the panel that formaldehyde should be presumed to pose a carcinogenic risk to humans.

show abstract

Studies on Induced Reversions at the Arginine Locus of Aspergillus chevalieri (Mangin)

Cited by 2 publications

References 14 publications

Report of the Federal Panel on Formaldehyde

Report of the Federal Panel on Formaldehyde

Report of the Federal Panel on Formaldehyde.

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