Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation

Agarwal, Ramesh; Diwanay, Sham; Patki, Pralhad Sadashiv; Patwardhan, Bhushan

doi:10.1016/s0378-8741(99)00065-3

Cited by 206 publications

(124 citation statements)

References 8 publications

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“…The IgG mediated formation of antigen-antibody complexes on the surface of mast cells and basophils results in the release of inflammatory mediators of anaphylaxis such as histamine, leukotrienes and prostaglandins (Postma, 1995;Agarwal et al, 1999;Dahanukar et al, 2002;Shanmugam et al, 2007). The effect of UNIM-352 on the degranulation of peritoneal mast cells in sensitized animals was studied and the results showed that UNIM-352 significantly inhibited antigen challenge induced degranulation of mast cells in a dose related manner and also protected the rats against mortality.…”

Section: Discussionmentioning

confidence: 99%

An Experimental Study to Evaluate the Anti-inflammatory and Immunmodulatory Effects of UNIM-352, a Polyherbal Preparation for Bronchial asthma

A.¹

2012

mpr

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This study was conducted to assess the possible anti-inflammatory and immuno-modulatory effects of UNIM-352, a polyherbal Unani preparation, which was used for bronchial asthma in traditional system of medicine. In KLH immunized rats, UNIM-352 (200 mg/kg and 400 mg/kg, orally for 14 days) attenuated the levels of the proinflammatory cytokines, TNF-α and IL-1β, and the Th2 cell derived cytokine, IL-4, in blood and BAL fluids, as compared to vehicle controls. Studies with acute anaphylaxis revealed that UNIM-352 prevented, antigen challenge induced mast cell degranulation in a dose related manner and reduced anaphylactic mortality. At both dose levels, UNIM-352 was able to significantly inhibit the serum IgE levels when compared to vehicle treated control group. All these effects were comparable to prednisolone that was used as reference standard for the experiment. In studies for cell mediated immunity, UNIM-352, at the dose level studied, did not have any appreciable influence on the DTH assay as measured by change in footpad thickness in immunized and challenged rats. These results indicated that UNIM-352 might have anti-inflammatory and immunomodulatory properties that may be contributing to its beneficial effects in bronchial asthma.

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Section: Discussionmentioning

confidence: 99%

An Experimental Study to Evaluate the Anti-inflammatory and Immunmodulatory Effects of UNIM-352, a Polyherbal Preparation for Bronchial asthma

A.¹

2012

mpr

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“…Since drugs augmented the circulating antibody titer, it was thought worthwhile to evaluate their effect on cyclophosphamide induced immunosuppression. A high degree of cell proliferation renders the bone marrow (Agrawal et al, 1999). In the case of cyclophosphamide-induced immunosuppression, plant extract was able to bring back the levels of WBC, RBC, and other blood parameters responsible for protection against cyclophosphamide.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory activity of petroleum ether extract ofAnacyclus pyrethrum

Sharma¹,

Thakur²,

Chauhan³

et al. 2010

Pharmaceutical Biology

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“…37,38) Epidemiological studies have almost confirmed that non steroidal anti-inflammatory drugs reduce the incidence of AD. 39) Foeniculum vulgare, 40) Boerhaavia diffusa, 41) Celastrus paniculatus, 42) Centella asiatica, 43) Cyperus rotundus, 44) Eclipta alba, 45) Elettaria cardamomum, 46) Phyllanthus emblica, 47) Glycyrrhiza glabra, 48) Ocimum sanctum, 49) Piper longum, 50) Zingiber officianale, 51) and Withania somnifera 52) have been proved as anti-inflammatory agents, which might protect from the development of inflammatory lesions in brain.…”

Section: Discussionmentioning

confidence: 99%

Memory Enhancing Activity of Abana: An Indian Ayurvedic Poly-Herbal Formulation

Parle

Mani

2007

JOURNAL OF HEALTH SCIENCE

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The present study was aimed at investigating the effects of Abana, an Ayurvedic herbomineral preparation on memory and brain cholinesterase activity in mice. Drug Abana was administered orally in three doses (50, 100 and 200 mg/kg) for fifteen days to different groups of young and aged mice. Elevated plus maze and passive avoidance apparatus served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine-and ageinginduced amnesia served as the interoceptive behavioral models. Brain cholinesterase activity was also estimated. Abana (50, 100 and 200 mg/kg, orally (p.o.)) produced a dose-dependent improvement in memory scores of young and aged mice. Furthermore, it reversed the amnesia induced by scopolamine (0.4 mg/kg, intraperitoneally (i.p.)) and diazepam (1 mg/kg, i.p.). Interestingly, brain cholinesterase activity was reduced by Abana administered orally for 15 days. It may prove to be a useful remedy for the management of Alzheimer's disease.

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Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation

Cited by 206 publications

References 8 publications

An Experimental Study to Evaluate the Anti-inflammatory and Immunmodulatory Effects of UNIM-352, a Polyherbal Preparation for Bronchial asthma

An Experimental Study to Evaluate the Anti-inflammatory and Immunmodulatory Effects of UNIM-352, a Polyherbal Preparation for Bronchial asthma

Immunomodulatory activity of petroleum ether extract ofAnacyclus pyrethrum

Memory Enhancing Activity of Abana: An Indian Ayurvedic Poly-Herbal Formulation

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