Studies on immunity to lymphocytic choriomeningitis virus

Zinkernagel, R. M.; Leist, Th.; Hengartner, Hans; Paulweber, Bernhard; Stitz, Lothar

doi:10.1007/bf02122453

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…A key finding of the present study is that these cells are apparently instrumental in maintaining the typical follicular organization in spleens and lymph nodes. Although evidence that antiviral CD8' T cells act cytolytically by cell contact in vivo is indirect (40)(41)(42) (48)(49)(50)(51)(52)(53). Detailed histopathological studies may be taken to support the hypothesis that CD8+-T-cell-dependent immunopathology may significantly contribute to the pathogenesis of AIDS; lymph node histopathology in patients with AIDS-related complex is often strikingly similar to that of mice suffering from LCMV-induced immunosuppression as shown here.…”

Section: Discussionmentioning

confidence: 99%

Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure.

Odermatt

Eppler

Leist

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

216

146

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Virus-induced acquired immune suppression in mice infected with lymphocytic choriomeningitis virus is shown here to be caused by the CD8+-T-cell-dependent elimination of macrophages/antigen-presenting cells. Surprisingly, this is associated with severe destruction of the follicular organization of lymphoid organs, indicating a crucial role for dendritic cells and marginal zone macrophages in maintaining follicular structure. Once established, this immunopathology cannot be readily reversed by the elimination of CD8+ effector cells. Such a T-cell-mediated pathogenesis may play a pivotal role in acquired virus-induced immunosuppression and may represent one strategy by which virus escapes immune surveillance and establishes persistent infections in initially immunocompetent hosts.

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Section: Discussionmentioning

confidence: 99%

Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure.

Odermatt

Eppler

Leist

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

216

146

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“…day Ϫ6), LCMV-infected (200 pfu i.p. day Ϫ4) peritoneal macrophages against LCMV-WE-infected MC57G target cells in a standard 51 Cr-release assay (32).…”

mentioning

confidence: 99%

A critical role for neutralizing-antibody-producing B cells, CD4⁺T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: Implications for adoptive immunotherapy of virus carriers

Planz

Ehl

Furrer

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

195

149

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Studies on immunity to lymphocytic choriomeningitis virus

Cited by 2 publications

References 8 publications

Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure.

Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure.

A critical role for neutralizing-antibody-producing B cells, CD4⁺T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: Implications for adoptive immunotherapy of virus carriers

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Studies on immunity to lymphocytic choriomeningitis virus

Cited by 2 publications

References 8 publications

Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure.

Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure.

A critical role for neutralizing-antibody-producing B cells, CD4+T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: Implications for adoptive immunotherapy of virus carriers

Contact Info

Product

Resources

About

A critical role for neutralizing-antibody-producing B cells, CD4⁺T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: Implications for adoptive immunotherapy of virus carriers