Studies on Human Foetal Haemoglobin. II. Foetal Haemoglobin Levels in Healthy Children and Adults and in Certain Haematological Disorders

The Effect of Methemoglobin Formation in Sickle Cell Disease*

“…It has also been observed, by using alkali denaturation and immunologic technique (35,36), that there is increase in fetal hemoglobin content of the mother's blood during the second trimester of normal pregnancy and during molar pregnancy. This has not been confirmed with sensitive measurements using the tryptophan fine-line spectrum after alkali denaturation (34). Nonetheless, the possibility that the hormonal environment might influence fetal hemoglobin synthesis appeared to us to warrant further investigation.…”

Hereditary nonspherocytic hemolytic disease associated with an altered phospholipid composition of the erythrocytes

“…Ways (34) recently described a patient with liver disease and a mild hemolytic process in which a similar alteration in the composition of the phospholipids appeared to revert towards normal when the liver disease improved. In the present investigation, (45,47). Enzymic deficiencies known to be associated with hereditary hemolytic disorders were excluded by direct assay, except for 2,3-diphosphoglycerate mutase and ATPase deficiencies.…”

The postnatal decline of hemoglobin F synthesis in normal full-term infants.

“…The duration of postnatal synthesis of Hb F is an issue that is now assuming increasing importance as information is being sought to further the understanding of the mechanisms, genetic and nongenetic, that control both the orderly switchover from Hb F to Hb A synthesis and the reappearance of Hb F in certain disease states (3). Furthermore, elevated levels of Hb F synthesis may persist in various congenital diseases, the most frequent of which are the hemoglobinopathies and thalassemias (4).…”