Studies on hemoglobin metabolism. II. Kinetics of clearance from circulation and hepatic uptake of hemoglobin-haptoglobin complex.

Tsunoo, Hajime; Higa, Yumi; Kino, Kuniki; Nakajima, Hiroshi; Hamaguchi, Hideo

doi:10.2183/pjab.53.18

Cited by 6 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HBPs are important components for heme detoxification and for recycling of heme and Fe, since they allow the targeting of heme to specific tissues such as the liver [58,59], while protecting other tissues against heme-mediated damage [58,60]. In humans, this sequestration and recycling of circulating heme and Hb during intravascular hemolysis and tissue damage, has been attributed to three main heme binding proteins: haptoglobin [59], hemopexin and albumin [58]. …”

Section: Introductionmentioning

confidence: 99%

Heme and blood-feeding parasites: friends or foes?

et al. 2010

View full text Add to dashboard Cite

Hemoparasites, like malaria and schistosomes, are constantly faced with the challenges of storing and detoxifying large quantities of heme, released from their catabolism of host erythrocytes. Heme is an essential prosthetic group that forms the reactive core of numerous hemoproteins with diverse biological functions. However, due to its reactive nature, it is also a potentially toxic molecule. Thus, the acquisition and detoxification of heme is likely to be paramount for the survival and establishment of parasitism. Understanding the underlying mechanism involved in this interaction could possibly provide potential novel targets for drug and vaccine development, and disease treatment. However, there remains a wide gap in our understanding of these mechanisms. This review summarizes the biological importance of heme for hemoparasite, and the adaptations utilized in its sequestration and detoxification.

show abstract