Studies on Growth Hormone Secretion in Protein-Calorie Malnutrition

Pimstone, B. L.; Barbezat, G. O.; Hansen, Jo‐Ida C.; Murray, P.

doi:10.1093/ajcn/21.5.482

Cited by 128 publications

(55 citation statements)

References 16 publications

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“…Leptin is produced and released in amounts directly proportional to the mass of adipose tissue in the body, signaling to the hypothalamus the amount of stored energy, as well as the regulation of food intake and thermogenesis (SAVINO et al, 2007). Protein restriction causes an increase in serum growth hormone performing lipolysis, providing organism maintenance through fatty acids, aided by corticosteroids, which change the peripheral energy source (PIMSTONE et al, 1968). Thus, leptin secretion decreases since there is less adipose tissue in these animals, decreasing the feedback process to the hypothalamus that limits the feeling of hunger, allowing excess food intake by the animal without the feeling of satiation.…”

Section: Discussionmentioning

confidence: 99%

Metabolic effects of early protein undernourishment and renourishment in wistar rats

Baptista¹,

Cavalli²,

Luiz³

et al. 2015

Biosci. J.

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ABSTRACT:Malnutrition remains an important public health condition by affecting mostly children. The present study aimed to examine the effects of prenatal protein undernourishment and postnatal renourishment on the metabolism of pre-adult animals. Forty-five male Wistar rats originating from different litters were used. The Nourished (N, n=15) and Undernourished (U, n=30) groups were maintained on proteic and hypoproteic diets (20% and 5% casein, respectively) from the intrauterine phase until the end of the experiment. The Renourished group (R) contained 15 animals, randomly chosen from U group, that consumed the N diet beginning on day 21 (weaning). All groups were maintained until day 60. The experimental data was acquired daily for body weight, feed and water intake, feces and urine excretion. Data analysis was made with the total results and the ratio between them. The U group animals developed uniformly sparse hair late and experienced intense sweating, features that were not observed during the experiment in the R and N animals groups. The R group had the largest weight gain and feed and water intake ratio/weight at experimental period, followed by the N group animals. The final body weight and food intake decreased gradually in the order N-R-U, but none of the other parameters showed a statistical difference between the N and R animals. Compared to groups N and R, the U group animals consumed 90% and 81% more food and water, respectively. Protein undernourishment induced metabolic dysfunction in the U group animals. The similarity in the experimental parameters of the N and R groups suggests that an early feeding correction was effective in reestablishing the organic functions of the R group animals.

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Section: Discussionmentioning

confidence: 99%

Metabolic effects of early protein undernourishment and renourishment in wistar rats

Baptista¹,

Cavalli²,

Luiz³

et al. 2015

Biosci. J.

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show abstract

“…When compared with those of healthy infants matched for age or size, the fasting GH levels found in untreated marasmus in the present study and others (39,44) must be considered normal, not "high." The very poor or delayed suppression is abnormal; this may be due to a poor or delayed glycemic stimulus, but this was not true in most of our cases, or in infants receiving intravenous glucose (3 1, 38, 39).…”

Section: Normal Infantsmentioning

confidence: 54%

“…Their inclusion in the group means helps to explain the variability in hormonal and metabolic responses found in our studies and in those of others, most of which make no mention of complicating infections. On the day after admission most infants had fasting BS in the low range reported by others (2,8,12,17,19,31,36,39) but two had levels of 124 and 137 mg/100 ml. The occurrence of similar levels with the same frequency in the healthy infants deprives this finding of special significance.…”

Section: Normal Infantsmentioning

confidence: 58%

“…The earliest determinations of fasting G H in untreated kwashiorkor found it to be consistently elevated (40); this has been confirmed (4,12,14,26,31,32,39). Elevated levels were not suppressed by induced hyperglycemia (31,38,39) and were not further raised by intravenous arginine (4,14), but dropped promptly after meals containing protein (39,40) or a mixture of essential amino acids (32).…”

Section: Marasmic Kwashiorkormentioning

confidence: 86%

“…Although it was recognized that impaired absorption would influence the results, and that the responses observed might not be maximal, we felt that they would be more representative of responses taking place when such infants are realimented than those to induced hyper-and hypoglycemia or to amino acid infusions (2,4,8,11,12,14,31,39,41). Because of the paucity of reported normal values in infants of different ages, and because control samples handled in the sample manner as the study samples would be more meaningful, we evaluated healthy infants selected to match the study cases in age and body size.…”

Section: Speculationmentioning

confidence: 99%

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