Studies on Familial Nephrosis

Vernier, Robert L.; Brunson, Joel G.; Good, Robert A.

doi:10.1001/archpedi.1957.02060040471001

Cited by 50 publications

(7 citation statements)

References 23 publications

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“…Hall and Roth (12) thought that the developing glomerular basement membrane in rats was intimately associated with the endothelium, whereas Benedetti and Marinozzi (13), from a study of rat kidneys, and Kurtz (14), from a study of human embryonic kidneys, proposed that glomerular basement membrane was a product of both endothelial and visceral epithelial cells, since it appeared to receive a contribution from each, in the form of a double membrane. Vernier (15), however, in examining human fetal kidneys, observed that the epithelial cytoplasm contained material which resembled the lamina densa of the glomerular basement membrane, both morphologically and in its reaction to silver impregnation. He interpreted these data as supporting the concept that the epithelium contributed to the formation and maintenance of the basement membrane.…”

Section: Discussionmentioning

confidence: 99%

Electron Microscopic Studies of Experimental Nephritis With Ferritin-Conjugated Antibody

Andres

Morgan

Hsu

et al. 1962

The Journal of Experimental Medicine

110

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The acute nephritis that rapidly follows the injection of antikidney serum is the result of a specific reaction between antigens localized in the glomeruli and antibodies contained in the nephrotoxic sera. The antibodies, demonstrated by means of the fluorescence technique, were found in greatest concentration apparently in or on the glomerular basement membrane of nephritic animals and were noted to remain there for many months (1). The precise localization of nephrotoxie globulin in the glomeruli, however, was dif]fieult to establish owing in part to the limited resolution of the ultraviolet light microscope and in part to the relatively thick sections employed.This paper reports the use of ferritin-conjugated antibody globulin (2) to identify the sites of antigen-antibody interaction by electron microscopy. This technique has been applied to the localization of viral and bacterial antigens (3-6). Preliminary studies from this laboratory on the application of ferritinconjugated antibody to the study of experimental glomerulonephritis have been described elsewhere (7). Materials and MethodsThe sera used to produce nephritis were the same rabbit antisera to rat kidney employed in groups I and 3 referred to in reference 1. Long-Evans rats, varying in age from 2 to 3 months, were injected intravenously on 2 or 3 successive days with a high titered antikidney serum which produced proteinuria and renal lesions within 24 hours. The animals were killed 1 week later.

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Section: Discussionmentioning

confidence: 99%

Electron Microscopic Studies of Experimental Nephritis With Ferritin-Conjugated Antibody

Andres

Morgan

Hsu

et al. 1962

The Journal of Experimental Medicine

110

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“…For over half a century, there have been scattered reports in the medical literature of familial nephrosis (2). Four siblings with nephrotic syndrome were described in a 1957 report (3). Pathology showed minimal change disease in some children, FSGS in others.…”

Section: Mendelian Geneticsmentioning

confidence: 99%

Inherited Podocytopathies

Pollak¹

2002

Journal of the American Society of Nephrology

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“…However, re cent evidence suggests that the filtrate passes between the visceral epithelial cells within the slit pores [1.11,33.37,56]. Because the glomerular filtration rate is usually normal in human nephrosis [40,62,63], the velocity of the flow' of filtrate must increase within the simplified slit pores. The viscosity in a capillary tube decreases in proportion to the velocity of llow because elongated rigid mac romolecules such as albumin and IgG align themselves with streamlines in the fluid [24,60].…”

Section: Introductionmentioning

confidence: 99%

Permselectivity: Relation between Foot Process Simplification and Macromolecular Configuration

Luke¹

1984

Kidney Blood Press Res

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The simplification of the foot processes of the glomerular epithelial cells is the structural hallmark of proteinuria in nephrotic man and animals. The increased shear force in a filtrate funnelled within the lamina densa to simplified slit pores may decrease the friction of macromolecules which are prolate ellipsoids (cigar-shaped). The permeability of rigid long narrow proteins such as albumin, transferrin and immunoglobulin G may selectively increase when the slit pore is converted from a wide serpentine to a straight narrow space.

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Studies on Familial Nephrosis

Cited by 50 publications

References 23 publications

Electron Microscopic Studies of Experimental Nephritis With Ferritin-Conjugated Antibody

Electron Microscopic Studies of Experimental Nephritis With Ferritin-Conjugated Antibody

Inherited Podocytopathies

Permselectivity: Relation between Foot Process Simplification and Macromolecular Configuration

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