Studies on Experimental Oxaluria in Pigs

Toxicology update

“…In the pig, 4550% of an oral dose of sodium oxalate was recovered in the urine. 33 In the dog, an oral dose of 1338 mg of sodium oxalate to a fasting animal resulted in anuria for several days followed by urinary excretion of 75% of the dose over the next 10 days; 11.5% was recovered in the feces. In a dog on a normal diet, 80% of a single oral 1000-mg dose was excreted over a period of 9 days.…”

Microbial degradation of oxalate in the gastrointestinal tracts of rodents and ruminants

“…Based on the above observations, these authors proposed that the reduced colonic rates of oxalate degradation observed in individuals with altered intestinal function due to enteric disease or resection may enhance oxalate availability in the colon and thereby contribute to increased absorption of dietary oxalate and hyperoxaluria, both of which are associated with these enteric abnormalities. Further studies are warranted before this "microbial" theory can be employed along with the solubility and permeability theories to explain the etiological basis of enteric hyperoxaluria Bruce and Bredehorn, 1961;Wilson and Harvey, 1977). and oxalate-balance studies in horses(McKenzie et al, 1981) led to the suggestion that the gastrointestinal microflora present in these animals may be responsible for the destruction of considerable amounts of oxalate in the ingesta.…”