Studies on experimental ancylostomiasis: Transfer of acquired immunity toAncylostoma caninum in mice through sensitized thymus and bone marrow cells

Abstract

An attempt has been made to transfer acquired immunity to Ancylostoma caninum infective larvae from infected Swiss albino female mice to nonimmune, isologous recipients of same sex, through immunized thymus and bone marrow cells. Immunized cells from donors infected with a single high dose of 1000 larvae were found to be more immunocompetent than cells from donors infected with a single, but low dose of 500 larvae.

Experimental Hookworm Infection in Laboratory animals: Parasite behavior, Immune response and Chemotherapeutic Studies

“…However, a significant reduction in the γ-globulin was seen in these animals except in the groups which received 4000 A. caninum larvae in mice [15]. Study on A caninum in mice has also provided information on the role of cellmediated immunity when passively transferred sensitized peritoneal exudate cells [16], small and large intestinal mesenteric lymph node cells [17], and thymus and bone marrow cells separately [18,19]. The activated immune cells transferred results show diminishing survival of migrating larvae in the tissue and due to the cause of earlier expulsion from the intestines with A. caninumin infection in mice [20].…”