Studies on energy‐linked reactions: Inhibition of oxidative phosphorylation and energy‐linked reactions by dibutyltin dichloride

Cain, Kelvin; Hyams, Robert L.; Griffiths, David E.

doi:10.1016/0014-5793(77)80877-6

Cited by 48 publications

(16 citation statements)

References 7 publications

(11 reference statements)

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“…At higher concentrations, dibutyltin dichloride was also observed to inhibit the oxidative phosphorylation processes in mitochondria. Both an interaction with the ATP synthase complex (Cain et al, 1977) and an uncoupling effect have been described (Penninks et al, 1983).…”

Section: Effects On Mitochondrial Respirationmentioning

confidence: 99%

Biological activity of organotin compounds—An overview

Snoeij

Penninks

Seinen

1987

Environmental Research

345

131

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As a consequence of the rapid expansion of the uses and applications of the organotin compounds, the concern about their environmental and health effects is increasing. The main subject of this overview is the current understanding of the mammalian toxicity of the organotin compounds. Four different types of target organ toxicity, namely neurotoxicity, hepatotoxicity, immunotoxicity, and cutaneous toxicity, are discussed in more detail. The effects of the organotin compounds on the mitochondfial and cellular level are summarized and discussed in relation to the mode of action of these compounds on the central nervous system, the liver and bile duct, the immune system, and the skin. © 1987 Academic Press, Inc. ORGANOTIN COMPOUNDS: APPLICATIONS AND TOXICITY Organotin CompoundsTin can be present as an element in a wide variety of both inorganic and organometallic compounds. Organometallic tin compounds or organotins are characterized by the presence of at least one covalent carbon-tin bond. Although tin may exist either in the Sn 2+ or in the Sn 4+ oxidation state, almost all organotins have a tetravalent structure. Depending on the number of organic moieties, the organotin compounds are classified as mono-, di-, tri-, and tetraorganotins. In compounds of industrial importance, methyl, butyl, octyl, and phenyl groups form the organic substituents, while the anion is usually chloride, fluoride, oxide, hydroxide, carboxylate, or thiolate. All alkyltin compounds refered to in this article contain unbranched saturated hydrocarbon side chains (n-alkyltins).

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Section: Effects On Mitochondrial Respirationmentioning

confidence: 99%

Biological activity of organotin compounds—An overview

Snoeij

Penninks

Seinen

1987

Environmental Research

345

131

View full text Add to dashboard Cite

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“…These differences in properties have been suggested to give rise to critical variations in the intracellular distribution of each agent Iizuka et al, 1991;Arakawa, 1992a, 1992b;Arakawa, 2000). Several organotin compounds are known to cause inhibition of ATP synthesis and inhibition of oxidative phosphorylation in mitochondria (Aldridge and Street, 1970;Selwyn et al, 1970;Dawson and Selwyn, 1975;Cain et al, 1977;Penninks et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

Analysis of mechanisms of cell death of T-lymphocytes induced by organotin agents

Tomiyama

Yamaguchi

Kuriyama

et al. 2009

Journal of Immunotoxicology

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“…Additionally, PCP has effects similar to butyltin (BT) compounds on NK lytic function and ATP levels (Whalen et al 1999; Dudimah et al 2007a,b) and glutathione and other sulfhydryl containing compounds have been shown to reverse the negative effects of BT compounds on ATP (Cain et al, 1977). Thus, we examined the ability of the antioxidants, reduced glutathione and vitamin E, to ameliorate the negative effects of PCP exposures on NK lytic function and ATP levels.…”

Section: Discussionmentioning

confidence: 99%

Pentachlorophenol decreases ATP levels in human natural killer cells

Nnodu

Whalen

2008

J of Applied Toxicology

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Pentachlorophenol (PCP) is used as a wood preservative and is found in human blood and urine. PCP causes significant decreases in the tumor-killing (lytic) function of human natural killer (NK) cells, a critical immune defense. The current study examined the association between decreased lytic function and decreased ATP levels, as well as the ability of antioxidants (vitamin E and reduced glutathione) to prevent PCP-induced decreases in either ATP levels or lytic function. Exposure of NK cells to 10μM PCP decreased ATP levels by 15% at 24 h, and exposure to 5 μM PCP decreased ATP levels by 32% at 48 h. No effects were seen with 0.5 μM at 48 h or with 5 μM at 24 h. However, 10 μM PCP decreased lytic function by 69% at 24h and 5 μM decreased it by 90% at 48 h. Even 0.5 μM PCP decreased lytic function by 46% at 48 h. None of these effects were prevented by pretreatment with 1 mM vitamin E or reduced glutathione.

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Studies on energy‐linked reactions: Inhibition of oxidative phosphorylation and energy‐linked reactions by dibutyltin dichloride

Cited by 48 publications

References 7 publications

Biological activity of organotin compounds—An overview

Biological activity of organotin compounds—An overview

Analysis of mechanisms of cell death of T-lymphocytes induced by organotin agents

Pentachlorophenol decreases ATP levels in human natural killer cells

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