Studies on Cytological Anomalies of Microbial Co-infections in Cervical Lesions

Mohanty, Gangotree; Nayak, Bhagyalaxmi; Padhy, Ashok Kumar

doi:10.1007/s40944-020-00417-4

Cited by 1 publication

(4 citation statements)

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“…The studies included in the meta-analysis, published from 1985 to 2021, comprised 67,856 women with cervical neoplasia in different stages and 933,697 healthy controls. Of the 35 studies, 11 were conducted in the Western Pacific [ 24 , 28 , 29 , 47 , 48 , 57 , 59 , 62 – 65 ], 9 in Europe and North America [ 27 , 41 – 44 , 46 , 49 , 51 , 52 ], 7 in South America [ 23 , 26 , 50 , 54 , 55 , 66 , 67 ], 4 in South-East Asia [ 22 , 56 , 58 , 60 ], and 4 in the Middle East and Africa [ 25 , 45 , 53 , 61 ]. All of these studies were observational: 20 case-control studies [ 22 , 25 , 41 , 42 , 44 – 51 , 54 , 58 , 61 – 65 , 67 ], 10 cross-sectional studies [ 23 , 24 , 26 – 28 , 55 , 57 , 59 , 60 , …”

Section: Resultsmentioning

confidence: 99%

“…Of the 35 studies, 11 were conducted in the Western Pacific [ 24 , 28 , 29 , 47 , 48 , 57 , 59 , 62 – 65 ], 9 in Europe and North America [ 27 , 41 – 44 , 46 , 49 , 51 , 52 ], 7 in South America [ 23 , 26 , 50 , 54 , 55 , 66 , 67 ], 4 in South-East Asia [ 22 , 56 , 58 , 60 ], and 4 in the Middle East and Africa [ 25 , 45 , 53 , 61 ]. All of these studies were observational: 20 case-control studies [ 22 , 25 , 41 , 42 , 44 – 51 , 54 , 58 , 61 – 65 , 67 ], 10 cross-sectional studies [ 23 , 24 , 26 – 28 , 55 , 57 , 59 , 60 , 66 ], and five cohort studies [ 29 , …”

Section: Resultsmentioning

confidence: 99%

“…All of these studies were observational: 20 case-control studies [ 22 , 25 , 41 , 42 , 44 – 51 , 54 , 58 , 61 – 65 , 67 ], 10 cross-sectional studies [ 23 , 24 , 26 – 28 , 55 , 57 , 59 , 60 , 66 ], and five cohort studies [ 29 , 43 , 52 , 53 , 56 ]. TV infection was assessed by cytology in 13 studies [ 27 , 29 , 43 , 45 , 47 – 49 , 52 , 56 , 58 , 61 , 62 , 67 ], PCR-based methods in nine studies [ 23 , 25 , 26 , 41 , 53 – 55 , 59 , 66 ], microscopy in eight studies [ 22 , 24 , 28 , 42 , 44 , 50 , 60 , 63 ], and other methods (ha...…”

Section: Resultsmentioning

confidence: 99%

“…Of the 35 studies, 11 were conducted in the Western Pacific [24,28,29,47,48,57,59,[62][63][64][65], 9 in Europe and North America [27, 41-44, 46, 49, 51, 52], 7 in South America [23,26,50,54,55,66,67], 4 in South-East Asia [22,56,58,60], and 4 in the Middle East and Africa [25,45,53,61]. All of these studies were observational: 20 case-control studies [22,25,41 [23, 25, 26, 41, 53-55, 59, 66], microscopy in eight studies [22,24,28,42,44,50,60,63], and other methods (hanging drop and medical reports) in five studies [46,51,57,64,65]. Based on methodological quality, 12 and 23 studies were categorized as moderate and low risk of bias studies, respectively (Table 1).…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

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Trichomonas vaginalis infection and risk of cervical neoplasia: A systematic review and meta-analysis

Fazlollahpour-Naghibi

Bagheri

Almukhtar³

et al. 2023

PLoS ONE

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Objectives The evidence in the literature regarding the relationship between Trichomonas vaginalis (TV) infection and cervical neoplasia is conflicting. The main aim of this study was to evaluate the magnitude of the risk of cervical neoplasia associated with TV infection. Methods A meta-analysis of observational studies, which provided raw data on the association of TV infection with cervical neoplasia, was performed. For this aim, we searched scientific databases (PubMed/Medline, Scopus, the Web of Sciences, and Embase) from inception to March 15, 2023. A random-effects model was applied by Stata 17.0 to calculate the pooled and adjusted odds ratios (ORs) with 95% confidence intervals (CI), including subgroup, sensitivity, and cumulative analyses to explore sources of heterogeneity. Results Of the 2584 records initially identified, 35 eligible studies contributed data for 67,856 women with cervical neoplasia, and 933,697 healthy controls from 14 countries were included. The pooled (2.15; 1.61–2.87; I2 = 87.7%) and adjusted (2.17; 1.82–2.60; I2 = 31.27%) ORs indicated a significant positive association between TV infection and the development of cervical neoplasia. There was no significant change in pooled and adjusted ORs by applying sensitivity and cumulative analyses, indicating the robustness of our findings. The pooled OR was significant in most sub-group analyses. There was no publication bias in the included studies. Conclusion Our findings indicated that women with a TV infection are at significantly greater risk of cervical neoplasia. Future research, particularly longitudinal and experimental studies, should be done to better understand the various aspects of this association.

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