Studies on cyclic AMP in different compartments of cerebrospinal fluid.

Tsang, D.; Lal, Samarthji; Ford, Robert M.; Aronoff, A.

doi:10.1136/jnnp.39.12.1186

Cited by 19 publications

(6 citation statements)

References 23 publications

(23 reference statements)

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“…The finding that cAMP does not show a cisternal: lumber gradient is consistent with previous results [26], Pres> it findings show a similar absence of gradient for cGMP. T ie lack of a gradient for melatonin, cAMP, and cGMP can c asserted with some confidence, as the known gradient for 5-HIAA [ 10] was seen in these samples.…”

Section: Discussionsupporting

confidence: 82%

“…Neither cAMP nor cGMP have significantly different levels in the CSF of men and women [9,26], so the group differences in cyclic nucleotide levels were due to melatonin administration and not the different sex ratio of the groups. When melatonin is injected into the cisterna magna of rab bits, it causes a nonsignificant decline in CSF cAMP and a significant rise in CSF cGMP [22].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Oral Melatonin Administration on Melatonin, 5-Hydroxyindoleacetic Acid, Indoleacetic Acid, and Cyclic Nucleotides in Human Cerebrospinal Fluid

Young¹,

Gauthier²,

Kiely³

et al. 1984

Neuroendocrinology

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Melatonin was given orally to patients undergoing diagnostic pneumoencephalography and various compounds were measured in the lumbar and cisternal CSF. Melatonin markedly increased plasma and CSF melatonin concentrations. The plasma: CSF melatonin ratios were similar in patients who received, and in those who did not receive, melatonin. This supports the idea that melatonin is released from pineal to blood and gets into the CSF via the blood. Melatonin did not affect CSF 5-hydroxyindoleacetic acid, which indicates that it has no effect on 5-hydroxytryptamine metabolism. Melatonin increased CSF indoleacetic acid significantly, indicating increased metabolism of tryptamine. Melatonin did not affect CSF cAMP levels, but increased cGMP levels. The effect on indoleacetic acid and cGMP was seen in both lumbar and cisternal CSF, suggesting that melatonin can have generalized actions throughout the CNS.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Effect of Oral Melatonin Administration on Melatonin, 5-Hydroxyindoleacetic Acid, Indoleacetic Acid, and Cyclic Nucleotides in Human Cerebrospinal Fluid

Young¹,

Gauthier²,

Kiely³

et al. 1984

Neuroendocrinology

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“…In some studies psychoactive drugs have been shown to alter cyclic AMP levels in mouse brain tissue and human CSF (16,17). Alteration of mammalian brain C-GMP levels by psychoactive drugs has also been found (18).…”

Section: Discussionmentioning

confidence: 99%

Central Nervous System Lupus Erythematosus

Kagen¹

1979

Arthritis & Rheumatism

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Cyclic-GMP (C-GMP), a normal constituent of the central nervous system, was found to be present in increased amounts in the cerebrospinal fluid (CSF) of systemic lupus erythematosus (SLE) patients with active neurologic disease. Twenty-four CSF samples from 17 patients with SLE were evaluated for C-GMP concentration by radioimmunoassay. This study extends our initial observations and examines three groups of SLE patients based on their clinical status a t the time of each lumbar puncture: those with active neurologic and psychologic abnormalities (group I), active neurologic abnormalities (group 11), and psychologic abnormalities without active neurologic involvement (group 111). Groups I and I1 had mean CSF C-GMP values of 3.1 nM f 0.64 (SE) and 4.1 nM * 0.10 respectively, which were both significantly higher than the mean for group 111 (1.2 nM & 0.43) (P < 0.05). Other CSF findings did not display this close correlation with activity of neurologic disease. In 4 SLE patients, significantly higher levels of CSF C-GMP were found on serial sampling during times when neurologic abnormalities were active.

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“…One conclusion to be drawn from these findings is that plasma levels of cyclic nucleotides are probably as poor an indicator of cyclic nucleotide metabolism in neural tissues as urinary excretion rates, and that more studies of nucleotide transport in extracellular space and CSF are needed. nucleotides in humans (Cramer et al, 1972a, b;Cramer et al, 1937b;Cramer, Renaud and Ortega-Suhrkamp, 1975;Heikkinen et al, 1974;Myllyla et a1,1975;Post, Goodwin, and Cramer, 1977;Trabucchi et al, 1977;Tsang et al, 1976;Welch, Meyer, and Chee, 1975). This may be due both to the fact that lumbar fluid reflects only to a limited extent ventricular fluid levels which may change rapidly and transiently, and also to spinal contributions (Cramer, Renaud, and Ortega-Suhrkamp, 1975;Tsang et al, 1976).…”

Section: Cyclic 3'5'-nucleotides In the Cerebrospinal Fluidmentioning

confidence: 99%

“…nucleotides in humans (Cramer et al, 1972a, b;Cramer et al, 1937b;Cramer, Renaud and Ortega-Suhrkamp, 1975;Heikkinen et al, 1974;Myllyla et a1,1975;Post, Goodwin, and Cramer, 1977;Trabucchi et al, 1977;Tsang et al, 1976;Welch, Meyer, and Chee, 1975). This may be due both to the fact that lumbar fluid reflects only to a limited extent ventricular fluid levels which may change rapidly and transiently, and also to spinal contributions (Cramer, Renaud, and Ortega-Suhrkamp, 1975;Tsang et al, 1976). In experimental animals, however, measurements of cAMP under different conditions such as drug treatments (Cramer and Lindl, 1972;Kiessling, Lindl, and Cramer, 1975;Sebens and Korf, 1975) and induced convulsions (Myllyla, 1976)have already contributed to our understanding of extracellular fluid CAMP, in that they have proved that CSF levels increase after various stimuli to cerebral cAMP formation and are regulated by transport mechanisms specific to this compartment.…”

Section: Cyclic 3'5'-nucleotides In the Cerebrospinal Fluidmentioning

confidence: 99%

Cyclic 3′, 5′‐nucleotides in extracellular fluids of neural systems

Cramer

1977

J of Neuroscience Research

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The cyclic nucleotides (CN) cAMP and cGMP occur in considerable amounts in body fluids such as urine, blood and cerebrospinal fluid (CSF). Whether changes in the CN concentrations of blood and CSF reflect metabolic events within the nervous tissues is a relevant question both in terms of possible roles of CN and of clinical diagnostic purposes. Studies are reviewed which show that CAMP is released from brain slices and from intact peripheral ganglia upon stimulation by electric pulses or exposure to biogenic amines in vitro. By using a prelabeling method with 14C-adenine evidence is presented that cAMP is released preferentially from a membrane-associated pool functionally linked to the action of neurotransmitters. In the CSF compartment which is closely related t o the extracellular space of the central nervous system, CN levels are in a dynamic equilibrium. An attempt is made to estimate the magnitude of flux rates following inhibition of efflux from the compartment. CN seem t o be cleared from the CNS, at least in part, by the choroid plexuses which contain high activities of CN phosphodiesterase but also of adenylate cyclase, possibly related to their secretory and homeostatic functions. Release into and rapid removal from extracellular compartments by transport and degradation may be important means t o limit the actions of CN in cells. Whether extracellular CN, in addition, have regulatory functions of their own still remains a matter of speculation.

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Studies on cyclic AMP in different compartments of cerebrospinal fluid.

Cited by 19 publications

References 23 publications

Effect of Oral Melatonin Administration on Melatonin, 5-Hydroxyindoleacetic Acid, Indoleacetic Acid, and Cyclic Nucleotides in Human Cerebrospinal Fluid

Effect of Oral Melatonin Administration on Melatonin, 5-Hydroxyindoleacetic Acid, Indoleacetic Acid, and Cyclic Nucleotides in Human Cerebrospinal Fluid

Central Nervous System Lupus Erythematosus

Cyclic 3′, 5′‐nucleotides in extracellular fluids of neural systems

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