Studies on correlation between cytological findings and HPV-test in ASC-US cases of uterine cervix

美津子, 立花; 美紀子, 吉田; 洋子, 大木; 祐子, 黒川; 篤子, 早田; 敏, 武田; 十九三, 河西; 竹一郎, 桑原; 武彦, 藤澤

doi:10.5795/jjscc.51.275

Cited by 2 publications

(1 citation statement)

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“…An ultrastructural study of HPV condyloma cases used transmission electron microscopy to demonstrate that HPV particles exist in association with condensed chromatin in the nuclear margin . In addition, Tachibana et al reported increased chromatin and partial nuclear contour thickening in ASC‐US cases with high‐risk HPV infection. In our study, however, nuclear enlargement without thickened nuclear contour was also observed in many high‐risk HPV‐positive cases.…”

Section: Discussionmentioning

confidence: 99%

A study of the relationship between nuclear contour thickening, nuclear enlargement and human papillomavirus infection in squamous cells

et al. 2019

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Objective To investigate the relationship between the morphological features of nuclear enlarged cells and human papillomavirus (HPV) infection in negative for intraepithelial lesion or malignancy (NILM) and atypical squamous cells of undetermined significance (ASC‐US). Methods In total, 128 Papanicolaou specimens comprising 41 ASC‐US cases and 87 NILM cases were examined. Cell morphological analysis was performed using both area ratio (nuclear area in cells with nuclear enlargement/nuclear area in normal intermediate cells) and nuclear contour thickening. High‐risk HPV was detected using the Uniplex E6/E7 polymerase chain reaction assay and logistic regression analyses of factors related to high‐risk HPV infection were performed. Results Nuclear contour thickening was present in 57.7% (64/111 cells) of high‐risk HPV positive cases and 21.8% (69/317 cells) of high‐risk HPV negative cases. There was a statistically significant association (P = 0.01) between high‐risk HPV infection and nuclear contour thickening. Nuclear contour thickening was approximately one‐third higher in NILM cases than in ASC‐US cases (odds ratio, 0.371; 95% confidence interval, 0.208–0.662) and three times higher in high‐risk HPV‐positive cases than in high‐risk HPV‐negative cases (odds ratio, 2.831; 95% confidence interval, 1.591–5.039). Conclusion Our results suggest that nuclear contour thickening in nuclear enlarged cells in NILM and ASC‐US cases may be a cellular finding associated with HPV infection.

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Section: Discussionmentioning

confidence: 99%