Studies on Compounds Related to Pyrazine. II. The Reaction of 3-Substituted-2-hydrazinoquinoxalines with Carbonyl Compounds

Solvent Free Microwave Accelerated Synthesis of Heterocyclic Thiazolidin-4-ones as Antimicrobial and Antifungal Agents

“…The starting material, 2-hydrazino-3-methylquinoxaline (1), was prepared as per the literature protocol. 26 All the synthesized compounds (3a-h) were characterized by elemental analysis (CHN) and spectral (IR, 1 H NMR and MS) data. Formation of hydrazones (2a-h) was confirmed by previously reported melting points 9 and the absence of primary amino group at 3350 cm -1 in IR spectra.…”

“…2-Hydrazino-3-methylquinoxaline (1) was prepared by reaction of 2-chloro-3-methyl quinoxaline with hydrazine hydrate as per the literature protocol. 26 Arene carbaldehyde-3-methylquinoxalin-2-yl hydrazones (2a-h) were prepared according to the general procedure. 9,27 General procedure.…”

Reaction of 2-hydrazino-3-methylquinoxaline with aryl-1,3-diketones: A structural reinvestigation

“…The starting compounds 2-hydrazino-3-methylquinoxaline (1) and aryl-β-diketones (2c-h) were prepared according to literature procedures. 11,16 Pentane-2,4-dione is commercially available. …”

Synthesis of Triazoloquinoxalines as Antitubercular Agents

“…Generally, syntheses of 1,2,4-triazoles are accomplished by the condensation of 2-hydrazinoderivatives with carboxylic acids at elevated temperature, 14 1,3-dipolar cycloaddition reaction of aromatic nitriles in presence of strong base and followed by hydrogen elimination, 15 photolysis of triazole-3-thiones, 16 and oxidation of arylhydrazones. [23][24][25][26][27][28] In view of our initial successes on the utilization of hypervalent iodine reagents for the synthesis of various heterocyclic compounds under solvent-free conditions, 29,30 and because of the biological significance of 1,2,4-triazole derivatives, we decided to develop an efficient and environmentally benign synthesis of 1,2,4-triazoles that proceeds under solvent-free conditions.…”