Studies on collagen metabolism in rats

Romen, W; Lange, Heinrich; Hempel, Klaus; Heck, Th.

doi:10.1007/bf02912075

Cited by 20 publications

(4 citation statements)

References 20 publications

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“…Thus, Cohen et al [3] found an increased synthesis of basement membranes 3 weeks after induction of diabetes. Romen et al [9], however, found a decreased formation eight weeks after streptozotocin injection. The influence of the degree of the metabolic dysregulation on the basement membrane formation was not investigated.…”

Section: Discussionmentioning

confidence: 96%

“…Besides a prolonged turnover of the basement membrane [3,9], increased synthesis thus constitutes an important pathogenetic factor in the development of microangiopathy.…”

Section: Discussionmentioning

confidence: 99%

“…Several authors have been able to show an increased synthesis of basement membrane collagen in in vitro studies with isolated glomeruli [2,4,5]. However, it has been critized that under these experimental conditions the basement membrane synthesis takes place very slowly and systemic influences are largely eliminated [1,9].…”

Section: Introductionmentioning

confidence: 97%

“…An increased incorporation of the tracer into the glomerular basement membrane of the diabetic rats was detected 9 days after alloxan injection. In diabetes of longer duration, Cohen et al [3] have recently found in vivo a raised basement membrane synthesis, whereas Romen et al [9] Offprint requests to: PD Dr. Ch. Hasslacher (address see above) 0300-9130/82/0181/0245/$ 1.40 observed a reduced formation.…”

Section: Introductionmentioning

confidence: 97%

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In vivo studies on basement membrane synthesis in diabetic and nondiabetic rats

et al. 1982

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In rats with chronic diabetes, the synthesis of glomerular basement membrane was investigated in vivo by injection of 3H-proline. Compared to the nondiabetic controls, the basement membrane synthesis was markedly raised. The formation of hydroxyproline as parameter for the synthesis of the collagen portion of the basement membrane increased to a somewhat greater extent than the incorporation of 3H-proline. Hydroxyproline formation and proline incorporation showed a close correlation with the blood sugar level in the diabetic rats.

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Section: Discussionmentioning

confidence: 96%

“…Besides a prolonged turnover of the basement membrane [3,9], increased synthesis thus constitutes an important pathogenetic factor in the development of microangiopathy.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

In vivo studies on basement membrane synthesis in diabetic and nondiabetic rats

et al. 1982

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Interstitial compartment pathology and spermatogenic disruption in testes from impotent diabetic men

1985

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Studies utilizing animal models of diabetes suggest that diabetic complications of impotence involve structural lesions in the testis as part of an overall defect in the pituitary-testicular axis. In the present study testicular biopsies from ten oligospermic and/or impotent men with diabetes were evaluated by light and electron microscopy. One biopsy was judged normal. The remaining tissue showed variable testicular pathology ranging from minimally to grossly affected. Seminiferous tubules had decreased tubule diameters, hyalinized tubule walls, and occluded lumina owing either to epithelial encroachment or cellular debris and exfoliated round germ cells. Sertoli cells were vacuolated and showed a high degree of apical cell membrane redundancy and degeneration. Although Sertoli-Sertoli cell junctional complexes appeared normal, Sertoli junctional specializations associated with spermatids were structurally abnormal or absent. All tubules were variably depleted of adluminal compartment germ cell types. The interstitial compartment was filled with a collagen-rich extracellular matrix concentrated around small blood vessels and seminiferous tubule walls. Capillaries and lymphatic endothelia appeared structurally abnormal and compromised by the interstitial "matrix expansion." Some Leydig cells contained a variable number of small to large lipid droplets, vacuoles, and secondary lysosomes. Results indicate the presence of tissue pathology in testes of impotent diabetic men. Discrete ultrastructural lesions in apical Sertoli cell cytoplasm are associated with spermatogenic disruption and morphological changes in the interstitial compartment suggest microvascular complications.

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Diabetic Nephropathy

Cohen¹

1987

The Polyol Paradigm and Complications of Diabetes

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Studies on collagen metabolism in rats

Cited by 20 publications

References 20 publications

In vivo studies on basement membrane synthesis in diabetic and nondiabetic rats

In vivo studies on basement membrane synthesis in diabetic and nondiabetic rats

Interstitial compartment pathology and spermatogenic disruption in testes from impotent diabetic men

Diabetic Nephropathy

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