1974
DOI: 10.1007/bf02128732
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Studies on Coccidioides immitis. XVII: Morphology of the parasite in relationship with the host immunoallergic condition in the experimental infection of the guineapig

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(5 citation statements)
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“…Disseminated coccidioidomycosis is a serious, chronic granulomatous disease whose incidence is increasing in endemic areas, particularly in the United States [ 5, 6]. Different species of animals and immunological conditions have been used to develop experimental models to study the physiopathological mechanisms of the disease [ 14–16, 25]. The early experiments conducted by Alejandro Posadas [ 26] showed, using a variety of warm‐ and cold‐blooded animals inoculated with C. immitis by different means, that cold‐blooded animals were refractory to infection.…”
Section: Discussionmentioning
confidence: 99%
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“…Disseminated coccidioidomycosis is a serious, chronic granulomatous disease whose incidence is increasing in endemic areas, particularly in the United States [ 5, 6]. Different species of animals and immunological conditions have been used to develop experimental models to study the physiopathological mechanisms of the disease [ 14–16, 25]. The early experiments conducted by Alejandro Posadas [ 26] showed, using a variety of warm‐ and cold‐blooded animals inoculated with C. immitis by different means, that cold‐blooded animals were refractory to infection.…”
Section: Discussionmentioning
confidence: 99%
“…The early experiments conducted by Alejandro Posadas [ 26] showed, using a variety of warm‐ and cold‐blooded animals inoculated with C. immitis by different means, that cold‐blooded animals were refractory to infection. Other studies have shown that experimental inoculation of the mycelial form of C. immitis leads to disseminated disease with variable mortality, which is dependent upon (a) the route of infection [ 1, 14]; (b) immunological status of the animal [ 25, 28, 29]; (c) the strain of C. immitis [ 30]; (d) animal species [ 15, 16, 22].…”
Section: Discussionmentioning
confidence: 99%
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