Studies on Ciliated Epithelia of the Human Genital Tract. II. The Mucociliary Wave Pattern of Fallopian Tube Epithelium

Weström, L; Mårdh, Per‐Anders; Mecklenburg, Claes von; Håkansson, C. H.

doi:10.1016/s0015-0282(16)42798-6

Cited by 35 publications

(31 citation statements)

References 6 publications

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“…The viscosity of the media should also be considered a frictional force. Reduced acceleration and frequency may cause frequencies of cilia beating that range from 5 to 20 Hz [40]. Cilia beating, pulsatile muscle contractions of the uterus and oviduct and sperm motility generate forces that move fluids [41].…”

Section: Discussionmentioning

confidence: 99%

Effect of micro-vibration culture system on embryo development

Hur

Park

Ryu

et al. 2013

J Assist Reprod Genet

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Purpose Micro-vibration culture system was examined to determine the effects on mouse and human embryo development and possible improvement of clinical outcomes in poor responders. Materials and methods The embryonic development rates and cell numbers of blastocysts were compared between a static culture group (n=178) and a micro-vibration culture group (n=181) in mice. The embryonic development rates and clinical results were compared between a static culture group (n=159 cycles) and a micro-vibration culture group (n=166 cycles) in poor responders. A micro-vibrator was set at a frequency of 42 Hz, 5 s/60 min duration for mouse and human embryo development.Results The embryonic development rate was significantly improved in the micro-vibration culture group in mice (p<0.05). The cell numbers of mouse blastocysts were significantly higher in the micro-vibration group than in the static culture group (p<0.05). In the poor responders, the rate of high grade embryos was not significantly improved in the micro-vibration culture group on day 3. However, the optimal embryonic development rate on day 5 was improved in the micro-vibration group, and the total pregnancy rate and implantation rate were significantly higher in the micro-vibration group than in the static culture group (p<0.05). Conclusions Micro-vibration culture methods have a beneficial effect on embryonic development in mouse embryos. In poor responders, the embryo development rate was improved to a limited extent under the micro-vibration culture conditions, but the clinical results were significantly improved.

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Section: Discussionmentioning

confidence: 99%

Effect of micro-vibration culture system on embryo development

Hur

Park

Ryu

et al. 2013

J Assist Reprod Genet

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“…The decrease was most probably not due to a reduction in the number of beating cilia, since MCW frequencies in areas of tubal epithelium with a low ciliary density (isthmus) and maintained as organ cultures for an equally long period of time did not differ from those of areas with a high ciliary density (infundibulum) (Westrom et al, 1977). The decrease in the MCW frequencies in the non-challenged specimens during culture maintenance corresponded approximately to observations by McGee et al, (1976), who determined the ciliary activity in the same type of organ cultures under a light microscope.…”

Section: Discussionmentioning

confidence: 93%

“…Variations in the ciliary beat frequency produce corresponding changes in the MCW pattern (Hakansson and Toremalm, 1965). The method has been used for quantitative determination of the ciliary activity in human Fallopian tubes maintained as organ cultures (Westrom et al, 1977). In premenopausal women the MCW frequency did not vary during the menstrual cycle and in different parts of the tubes.…”

Section: Discussionmentioning

confidence: 99%

Studies of ciliated epithelia of the human genital tract. 3: Mucociliary wave activity in organ cultures of human Fallopian tubes challenged with Neisseria gonorrhoeae and gonococcal endotoxin.

Mårdh¹,

Baldetorp²,

Håkansson³

et al. 1979

Sexually Transmitted Infections

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Quantatitive determinations of the mucociliary activity of human Fallopian tube epithelium maintained as organ cultures were performed using a light beam reflex method. In noninfected organ cultures the mucociliary wave (MCW) frequency slowly decreased during the first 54 hours of culture maintenance. In organ cultures experimentally infected with fresh isolates of Neisseria gonorrhoeae producing T1/T2 colonies the MCW frequency either decreased to subnormal values or completely ceased whereas in organ cultures infected with a laboratoryadapted gonococcal strain the MCW frequencies remained within normal range. In organ cultures exposed to gonococcal endotoxin prepared from the laboratory-adapted strain, as well as in cultures in which cell-free filtrates of medium from organ cultures infected with N. gonorrhoeae (producing T1/T2 colonies) were added to the culture medium, the ciliary activity decreased and subsequently ceased. The same phenomenon occurred when organ cultures were challenged with Escherichia coli endotoxin. The ciliostatic effect appeared before any morphological changes in the surface epithelium, including the cilia, were demonstrable by scanning electron microscopy.

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“…L'activité ciliaire de l'oviducte chez l'homme a été étudiée par Westrôm et al [1977], Leurs résultats indiquent que les cils de l'épithélium de la trompe utérine chez la femme battent avec une fréquence uniforme sur toute la longueur de l'organe et durant toutes les phases du cycle menstruel. Blandau [1978], dans une étude comparative concernant le transport de l'ovule, souligne également le rôle des cils dans la migration de l'ovule fécondé.…”

Section: Discussionunclassified

“…Des travaux expérimentaux effectués chez diverses espèces animales ont démon tré le rôle primordial joué par les cellules ciliées de la trompe dans le transport de l'ovule en direction de l'utérus [Odor et Blandau, 1973;Westrôm et al, 1977], Dans la région du pavillon de la trompe, en parti culier, les cils semblent seuls capables de transporter l'ovule, sans contribution de l'activité contractile de la paroi de l'oviducte à cet endroit [Halbert et al, 1976].…”

Section: Introductionunclassified

Présence de microcils sur l’extrémité apicale des cils de l’épithélium de la trompe uteriné

Foroglou-Kerameos¹,

Manthos²,

Bontis³

et al. 1983

Cells Tissues Organs

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The role played by the ciliated cells of the salpinx in the transport of the ovum has been the subject of numerous studies. In this work we examined the ultrastructure of the cilia of the ampullary portion of the oviductal epithelium in a series of mammals and in man. We found the classical structure of the motile cilia. The free part of the cilia, surrounded by the cell membrane, is composed by nine peripheral doublets and by a pair of central microtubules. In the species we examined, we had the occasion to observe an ultrastructural particularity of the cilia. It is about a group of microcilia placed on their apical extremity. These formations were observed in longitudinal sections and appeared aligned on the top of the cilium. They have a length of 200–300 Å and a diameter of 100 Å. Their number varies with the species examined. The proportion of cilia which presented microcilia is also different from species to species. The functional role of the microcilia is unknown.

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Studies on Ciliated Epithelia of the Human Genital Tract. II. The Mucociliary Wave Pattern of Fallopian Tube Epithelium

Cited by 35 publications

References 6 publications

Effect of micro-vibration culture system on embryo development

Effect of micro-vibration culture system on embryo development

Studies of ciliated epithelia of the human genital tract. 3: Mucociliary wave activity in organ cultures of human Fallopian tubes challenged with Neisseria gonorrhoeae and gonococcal endotoxin.

Présence de microcils sur l’extrémité apicale des cils de l’épithélium de la trompe uteriné

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