Studies on Chemical Composition and Antioxidant Activity of <i>Rudbeckia triloba</i>

Moldovan, Zenovia; Buleandră, Mihaela; Oprea, Eliza; Mînea, Zamfirica

doi:10.1155/2017/3407312

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…Medicinal plants that possess antioxidant activity can limit the unfavourable effect of ROS through accepting an electron, subsequently forming a more stable product. From the four major plants' secondary metabolites, alkaloid, flavonoid glycoside, phenolic, terpene, and phenolic compounds are known to show the most potent antioxidant activity, along with other physiological properties such as anti-microbial and anti-inflammatory activity [47][48][49].…”

Section: Citrullus Colocynthist 1000mentioning

confidence: 99%

Anti-Proliferative, Cytotoxic and Antioxidant Properties of the Methanolic Extracts of Five Saudi Arabian Flora with Folkloric Medicinal Use: Aizoon canariense, Citrullus colocynthis, Maerua crassifolia, Rhazya stricta and Tribulus macropterus

Yonbawi

Abdallah

Alkhilaiwi

et al. 2021

Plants

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Saudi Arabian flora have a history of use as folklore remedies, although such properties have yet to be explored rigorously, and the safety of such remedies should be assessed. This study determined the anti-proliferative, cytotoxic, and antioxidant properties of extracts of the following five plants indigenous to Saudi Arabia: Aizoon canariense, Citrullus colocynthis, Maerua crassifolia, Rhazya stricta, and Tribulus macropterus. The aerial parts of the five plants were collected from various locations of the western and northern regions of Saudi Arabia and used to prepare methanolic extracts. Three approaches were used to determine the proliferation and cytotoxicity effects using HaCaT cells: MTT, FACS, and confocal microscopy. Meanwhile, two approaches were used to study the antioxidant potential: DPPH (acellular) and RosGlo (cellular, using HaCaT cells). C. colocynthis possessed anti-proliferative activity against HaCaT cells, showing a significant decrease in cell proliferation from 24 h onwards, while R. stricta showed significant inhibition of cell growth at 120 and 168 h. The IC50 values were determined for both plant extracts for C. colocynthis, with 17.32 and 16.91 µg/mL after five and seven days of treatment, respectively, and for R. stricta, with 175 and 105.3 µg/mL after five and seven days of treatment. R. stricta and M. crassifolia exhibited the highest capacities for scavenging the DPPH radical with IC50 values of 335 and 448 µg/mL, respectively. The subsequent ROS-Glo H2O2 assay confirmed these findings. The R. stricta and M. crassifolia extracts showed potent antioxidant activity in both acellular and cellular models. The C. colocynthis extract also demonstrated significant anti-proliferation and cytotoxic activity, as did the R. stricta extract. These properties support their usage in folk medicine and also indicate a further potential for development for holistic medicinal use or as sources of new active compounds.

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Section: Citrullus Colocynthist 1000mentioning

confidence: 99%

Anti-Proliferative, Cytotoxic and Antioxidant Properties of the Methanolic Extracts of Five Saudi Arabian Flora with Folkloric Medicinal Use: Aizoon canariense, Citrullus colocynthis, Maerua crassifolia, Rhazya stricta and Tribulus macropterus

Yonbawi

Abdallah

Alkhilaiwi

et al. 2021

Plants

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“…Similarly, the major components of R. hirta essential oil were germacrene D (23.6%), δ-cadinene (16.2%), β-caryophyllene (4.7%), γ-muurolene (8.1%), as well as (E)-β-ocimene (15.2%) and (2E)-hexenal (20.2%) [43]. The leaf essential oil of Rudbeckia triloba, collected in Bucharest, Romania, was rich in monoterpene hydrocarbons, α-pinene (46.0%), sabinene (9.6%), and β-phellandrene (24.6%), along with germacrene D (6.1%), but devoid of limonene [73]. Thus, there do not seem to be any consistent chemical markers for the Rudbeckia genus.…”

Section: Rudbeckia Laciniata Lmentioning

confidence: 99%

Volatile Compositions and Antifungal Activities of Native American Medicinal Plants: Focus on the Asteraceae

Lawson

Sharp

Powers

et al. 2020

Plants

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In the past, Native Americans of North America had an abundant traditional herbal legacy for treating illnesses, disorders, and wounds. Unfortunately, much of the ethnopharmacological knowledge of North American Indians has been lost due to population destruction and displacement from their native lands by European-based settlers. However, there are some sources of Native American ethnobotany remaining. In this work, we have consulted the ethnobotanical literature for members of the Asteraceae used in Cherokee and other Native American traditional medicines that are native to the southeastern United States. The aerial parts of Eupatorium serotinum, Eurybia macrophylla, Eutrochium purpureum, Polymnia canadensis, Rudbeckia laciniata, Silphium integrifolium, Smallanthus uvedalia, Solidago altissima, and Xanthium strumarium were collected from wild-growing plants in north Alabama. The plants were hydrodistilled to obtain the essential oils and the chemical compositions of the essential oils were determined by gas chromatography–mass spectrometry. The essential oils were tested for in-vitro antifungal activity against Aspergillus niger, Candida albicans, and Cryptococcus neoformans. The essential oil of E. serotinum showed noteworthy activity against C. neoformans with a minimum inhibitory concentration (MIC) value of 78 μg/mL, which can be attributed to the high concentration of cyclocolorenone in the essential oil.

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“…Meanwhile, the TFC and TPC depends on their molecular structure, availability of phenolic hydrogen, and ability to stabilize the resulting HO and NO radicals via Hdonation. 22 The isolated compounds are pseudo-alkaloids and also known as alkamides. Alkamides alone showed no antioxidant activity, while if present in the extract are reported to increase the antioxidative potential.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Utilization of Agro-Waste of Piper longum for a Potential Pancreatic Lipase Inhibitor

Gaur

Tiwari

Shanker

2022

ACS Agric. Sci. Technol.

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The present study demonstrates the alternative source for pseudoalkaloids as well as the utilization of the agricultural wastes of Piper longum (PiL) as possible antiobesity agents. HPLC-based bioactivity-guided micro-fractionation of PiL root has resulted in five known compounds, piplartine (1), piperlonguminine (2), piperine (3), piperanine (5), pellitorine (6), and a new compound, piperdardine (4). Isolated compounds (1–6) were evaluated for their pancreatic lipase (PL) inhibitory potential. Pellitorine (PTR) was the most active component with IC50 = 3.35 μg/mL, which inhibited PL reversibly and in a mixed-type manner. The synergistic effect of PTR with orlistat (0.17 μM) was also observed at a concentration lower than 15.70 μM. The findings of Fourier transform infrared spectral studies demonstrated the structural compactness of PL with PTR. The thermodynamic studies have confirmed the binding interaction of PTR with PL as hydrophobic. Furthermore, molecular docking studies showed that PTR interacted in the catalytic active amino side residue (Ser153-Asp80-His264) of the protein (1ETH) by hydrogen bonds with affinity (ΔG = −7.0 kcal/mol). The findings of the study support PTR as a potential lead for further validation in animal studies to lead toward clinical translation as an anti-obesity supplement.

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Studies on Chemical Composition and Antioxidant Activity of Rudbeckia triloba

Cited by 10 publications

References 25 publications

Anti-Proliferative, Cytotoxic and Antioxidant Properties of the Methanolic Extracts of Five Saudi Arabian Flora with Folkloric Medicinal Use: Aizoon canariense, Citrullus colocynthis, Maerua crassifolia, Rhazya stricta and Tribulus macropterus

Anti-Proliferative, Cytotoxic and Antioxidant Properties of the Methanolic Extracts of Five Saudi Arabian Flora with Folkloric Medicinal Use: Aizoon canariense, Citrullus colocynthis, Maerua crassifolia, Rhazya stricta and Tribulus macropterus

Volatile Compositions and Antifungal Activities of Native American Medicinal Plants: Focus on the Asteraceae

Utilization of Agro-Waste of Piper longum for a Potential Pancreatic Lipase Inhibitor

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