Studies on cardiotonic agents. II. Synthesis of novel phthalazine and 1,2,3-benzotriazine derivatives.

Abstract

A series of phthalazine and 1,2,3-benzotriazine derivatives which have heterocyclylpiperidino groups was synthesized and tested for cardiotonic activity in anesthetized dogs. Several 6,7-dimethoxyphthalazine derivatives showed relatively potent cardiotonic activity comparable to that of amrinone.

An Efficient Three Component Synthesis of 1H-Indazolo[2, 1-b]phthalazine-triones Catalyzed by Orthophosphoric Acid in Water-Phenol System

“…Amongst, nitrogen heterocyclic containing a phthalazine moiety was reported to possess anticonvulsant 10 , cardiotonic 11 , vasorelaxant 12 antimicrobial 13 , anti-inflammatory 14 , antifungal 15 and anticancer 16,17 activities. Newly, three-RESEARCH ARTICLE component reactions of dimedone (5,5- 23 , N-halo sulphonamides 24 , silica supported poly phosphoric acid 25 , 26 Mg(HSO 4 ) 2 , phosphor sulfonic acids 27 , nano silica sulphuric acid 28 , sulfonated polyethylene glycol 29 and boron sulfonic acid 30 .…”

Ionic Liquid 4-(3-Methyl-1-imidazolio)-1-butanesulfonic Acid Hydrogen Sulfate-catalyzed Synthesis of Phthalazinetrione Derivatives

“…Heterocycles containing the phthalazine moiety show some pharmacological and biological activities [3]. Phthalazine derivatives have been reported to possess anticonvulsant [4], cardiotonic [5], vasorelaxant [6], cytotoxic [7], antimicrobial [8], antifungal [9], anticancer [10], and anti-inflammatory activities [11]. In addition, these compounds show good promise as new luminescence materials and fluorescence probes [12].…”

Heteropoly Acid in Ionic Liquid - An Efficient Catalyst for the Preparation of 2H-Indazolo[2,1-b]Phthalazine-Triones

“…Phthalazine derivatives were reported to possess vasorelaxant [2], cardiotonic [3], and anticonvulsant [4], activities. Therefore, a number of methods have been reported in the literature for the synthesis of phthalazine derivatives [4][5][6][7][8][9][10][11].…”