Studies on carbohydrate metabolism in rat kidney slices. III. Effect of adrenalectomy and hypophysectomy on glucose uptake and glucose formation

Teng, Ching Tseng

doi:10.1016/0003-9861(55)90176-4

Cited by 14 publications

(11 citation statements)

References 13 publications

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“…The increased renal glucose release found in our Type 1 diabetic patients is consistent with studies demonstrating increased glucose production and gluconeogenic enzyme activity in kidneys of streptozotocin /alloxan diabetic animals [32][33][34][35][36][37][38][39] and the recent report of increased renal glucose release in Type 2 diabetic patients [9]. Although the increase in renal glucose release of our patients was roughly comparable to the increase in their hepatic glucose release, such quantitative comparisons should be viewed with caution given the limits of precision in balance calculations with organs having high blood flows such as the kidney and liver.…”

Section: Discussionsupporting

confidence: 90%

Increased renal glucose metabolism in Type 1 diabetes mellitus

et al. 2005

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Section: Discussionsupporting

confidence: 90%

Increased renal glucose metabolism in Type 1 diabetes mellitus

et al. 2005

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“…Early studies in animals showed an increase in the rate of glucose infusion required to maintain euglycaemia when the liver and kidneys were removed as compared to when only the liver was excised [41,42]. Furthermore experimental diabetes in animals results in increased renal gluconeogenesis and glucose production in vitro [43,44]. Recently increased renal glucose production has been described in patients with Type 2 diabetes which could contribute to the ensuing hyperglycaemic state [45].…”

Section: Discussionmentioning

confidence: 99%

Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney

et al. 2003

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Aims/hypothesis. To study the secondary consequences of impaired suppression of endogenous glucose production (EGP) we have created a transgenic rat overexpressing the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) in the kidney. The aim of this study was to determine whether peripheral insulin resistance develops in these transgenic rats. Methods. Whole body rate of glucose disappearance (R d ) and endogenous glucose production were measured basally and during a euglycaemic/hyperinsulinaemic clamp in phosphoenolpyruvate carboxykinase transgenic and control rats using [6-3 H]-glucose. Glucose uptake into individual tissues was measured in vivo using 2-[1-14 C]-deoxyglucose. Results. Phosphoenolpyruvate carboxykinase transgenic rats were heavier and had increased gonadal and infrarenal fat pad weights. Under basal conditions, endogenous glucose production was similar in phosphoenolpyruvate carboxykinase transgenic and control rats (37.4±1.1 vs 34.6±2.6 µmol/kg/min). Moderate hyperinsulinaemia (810 pmol/l) completely suppressed EGP in control rats (−0.6±5.5 µmol/kg/min, p<0.05) while there was no suppression in phosphoenolpyruvate carboxykinase rats (45.2±7.9 µmol/kg/min). Basal R d was comparable between PEPCK transgenic and control rats (37.4±1.1 vs 34.6±2.6 µmol/kg/min) but under insulin-stimulated conditions the increase in R d was greater in control compared to phosphoenolpyruvate carboxykinase transgenic rats indicative of insulin resistance (73.4±11.2 vs 112.0±8.0 µmol/kg/min, p<0.05). Basal glucose uptake was reduced in white and brown adipose tissue, heart and soleus while insulin-stimulated transport was reduced in white and brown adipose tissue, white quadriceps, white gastrocnemius and soleus in phosphoenolpyruvate carboxykinase transgenic compared to control rats. The impairment in both white and brown adipose tissue glucose uptake in phosphoenolpyruvate carboxykinase transgenic rats was associated with a decrease in GLUT4 protein content. In contrast, muscle GLUT4 protein, triglyceride and long-chain acylCoA levels were comparable between PEPCK transgenic and control rats. Conclusions/interpretation. A primary defect in suppression of EGP caused adipose tissue and muscle insulin resistance. [Diabetologia (2003[Diabetologia ( ) 46:1338[Diabetologia ( -1347

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“…McGuinness et al (55) demonstrated that an infusion with cortisol, glucagon, and epinephrine increased renal glucose release in dogs. Earlier, Teng (18) and Landau (19) had reported that renal cortical slices from cortisol-treated rats had increased both renal glucose release and gluconeogenesis. Data in humans are limited to the effects of insulin (53,56), glucagon (57), and epinephrine (58).…”

Section: Hormonal Control Of Renal Glucose Release -mentioning

confidence: 99%

“…Four years later, Teng (18) reported that renal cortical slices taken from animals with experimentally induced diabetes released glucose at an increased rate, but that treatment of the animals with insulin could reverse this effect. In 1960, using a similar model, Landau (19) demonstrated that gluconeogenesis from pyruvate was increased more than twofold by the diabetic kidney.…”

Section: Early Nonhuman Studies -In 1938 Bergman Andmentioning

confidence: 99%

Renal Gluconeogenesis

et al. 2001

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Renal GluconeogenesisIts importance in human glucose homeostasis R E V I E W A R T I C L EStudies conducted over the last 60 years in animals and in vitro have provided considerable evidence that the mammalian kidney can make glucose and release it under various conditions. Until quite recently, however, it was generally believed that the human kidney was not an important source of glucose except during acidosis and after prolonged fasting. This review will summarize early work in animals and humans, discuss methodological problems in assessing renal glucose release in vivo, and present results of recent human studies that provide evidence that the kidney may play a significant role in carbohydrate metabolism under both physiological and pathological conditions. R e v i e w s / C o m m e n t a r i e s / P o s i t i o n S t a t e m e n t s

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Studies on carbohydrate metabolism in rat kidney slices. III. Effect of adrenalectomy and hypophysectomy on glucose uptake and glucose formation

Cited by 14 publications

References 13 publications

Increased renal glucose metabolism in Type 1 diabetes mellitus

Increased renal glucose metabolism in Type 1 diabetes mellitus

Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney

Renal Gluconeogenesis

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