Studies on Cancerocidal Substances. XIII. Effect of some Quinones and Related Compounds upon the Yoshida Sarcoma

Torigoe, Masahiro

doi:10.1248/cpb1953.3.337

Cited by 6 publications

(1 citation statement)

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“…The structural characterization of compounds 12 , 13 , 14 , 18 , 22 , and 23 has already been described [ 34 , 45 , 46 ]. Compounds 15 , 16 , 17 , 20 , and 21 have already been synthesized, although their complete spectroscopic data were not given [ 47 , 48 , 49 , 50 , 51 ]. Structures for 15 , 16 , 17 , 20 , and 21 and the remaining compounds are supported by the following spectroscopic data:…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Biological Evaluation of 2,5-Bis(alkylamino)-1,4-benzoquinones

et al. 2010

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A series of twelve 2,5-bis(alkylamino)-1,4-benzoquinones were prepared in yields ranging from 9–58% via the reaction between p-benzoquinone and various amines. The structures of the synthesized compounds were confirmed by IR, 1H- and 13C-NMR and MS analyses. The phytotoxicity of the 2,5-bis(alkylamino)-1,4-benzoquinones was evaluated against two crop species, Cucumis sativus and Sorgum bicolor, at 1.0 × 10-3 mol/L. In general, the quinones displayed inhibitory effects on the dicotyledonous species C. sativus (7–74%). On the other hand stimulatory effects were observed on S. bicolor (monocotyledonous). Similar results were observed in the biological assays carried out with the weed species Ipomoea grandifolia (dicotyledonous) and Brachiaria decumbens (monocotyledonous). In addition, the cytotoxicity of the 2,5-bis(alkylamino)-1,4-benzoquinones was assayed against HL-60 (leukemia), MDA-MB-435 (melanoma), SF-295 (brain) and HCT-8 (colon) human cancer cell lines and human peripheral blood mononuclear cells (PBMC), as representatives of healthy cells, using a MTT and an Alamar Blue assay. Compound 12 was the most active, displaying cytotoxicity against all cancer cell lines tested.

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