Studies on Bone Marrow in Hyperglobulinemia

Two Cases of Marrow Failure With Massive Marrow Plasmocytosis Simulating Myelomatosis

“…usually accompany any considerable degree of secondary marrow plasmocytosis (Clark and Muirhead, 1954), and, conversely, it has been found that patients with an altered pattern usually have some marrow plasmocytosis (Bing and Plum, 1937). Some authorities speak of a fairly close correlation between the degree of alteration in thpattern and the extent of the marrow plasmocytosis (Bing and Plum, 1937;Jarrold and Vilter, 1949;Clark and Muirhead, 1954), but others have failed to confirm this (Berlin, Wallace, and Meyer, 1950), probably because the marrow plasmocytosis does not necessarily reflect the infiltration in other organs such as the spleen (Paris and Bakke, 1956). The usual alteration in plasma proteins is an increase in the gamma globulin, but it may not be discerned unless electrophoresis is carried out, or when detected it may be accepted as evidence of myelomatosis.…”