Studies on Biological Activity of Cyclic Imide Compounds

Fujinami, Akira; Ozaki, Tatsuo; Nodera, Katsuji; Tanaka, Kuniji

doi:10.1080/00021369.1972.10860251

Cited by 49 publications

(17 citation statements)

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“…The reaction of aniline or its derivatives with maleic anhydride is well-known, because the product maleanilic acid or N-substituted maleanilic acid can be used to prepare the maleimides which are an important class of substrates for biological as chemical probes of protein structure [1], as a protective and curative fungicide [2] and in polymer chemistry as photoinitiators for free-radical polymerization [3,4] and monomers in polymaleimides or their copolymers synthesis.…”

Section: Introductionmentioning

confidence: 99%

Solvent free preparation of N-substituted maleanilic acid

Saedi¹

2012

Bull. Chem. Soc. Eth.

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ABSTRACT. Six N-maleanilic acids namely N-(4-carboxy)maleanilic acid (CAMAA), N-(4-bromo)maleanilic acid (BMAA), N-(4-hydroxy)maleanilic acid (HMAA), N-(3-hydroxy)maleanilic acid (mHMAA), N-(4-chloro)maleanilic acid (CMAA) and N-(4-methyl)maleanilic acid (MMAA) were prepared by solvent free reaction between maleic anhydride and a 4-carboxy, 4-bromo, 4-hydroxy, 3-hydroxy, 4-chloro and 4-methyl aniline derivatives in good to excellent yield. FT-IR, 1 H-NMR and 13 C-NMR spectra revealed the confirmation of these compounds in good agreement.

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Section: Introductionmentioning

confidence: 99%

Solvent free preparation of N-substituted maleanilic acid

Saedi¹

2012

Bull. Chem. Soc. Eth.

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“…Previous workers (18)(19) have demonstrated that N-arylmaleimides are fungicidal against a wide spectrum of phytopathogenic fungi and damping of diseases. In addition.…”

Section: Introduction and Discussionmentioning

confidence: 99%

Novel Imides Amino Acids and Dipeptide Derivatives

El-Sayed

2009

Al-Azhar Bulletin of Science

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Some novel imides derivatives condensed with different amino acids using THF-Et3N method, afforded an excellent yield of compounds 3-8, 20-23b, 32-35b. some of these compounds react with CH3OH-SOCl2 mixture to give corresponding methyl esters 9-11, 24-25, 36-37 Hydrazinolysis of some methyl esters give hydrazides 12-14, 26-27 some dipeptides derivatives 15-17, 28-29, 38-40 were prepared using Dicyclohexylcarbodiimide DCC method, some spectra data were briefly discussed.

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“…This conclusion should also be valid for various series of the cyclic 1V phenylimide fungicides such as N phenyl-1,2-d•imethylcyclopropanedicarboximides, 3-phenyloxazolidine-2,4-diones, and 3-phenylimidazolidine-2,4-diones. [9][10][11][12][13]18 …”

Section: Applicationmentioning

confidence: 99%

Computer-Assisted Prediction of Favorable Substituents for High Bioactivity in Congeners

et al. 1988

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A computer program called PREHAC was developed. This aids in the prediction of highly bioactive compounds among congeners in series of aliphatic monosubstituted derivatives and aromatic mono-, di-and tri-substituted ones, based on the Hansch-Fujita method. The PREHAC program is applicable to two phases included in the computer-assisted lead optimization: the development of a QSAR equation and the decision about the direction of structural modification based on the correlation, that is, the selection of substituent. This program was designed to search the Master Data file of 13 sets of physicochemical parameter values for 408 useful substituents. From the input of substituent names, activity values, and information on the combination of parameters, or from the input of the coefficients and intercept of the QSAR equation, the predicted high-ranking derivatives will be printed out. An example is given.

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Studies on Biological Activity of Cyclic Imide Compounds

Cited by 49 publications

References 0 publications

Solvent free preparation of N-substituted maleanilic acid

Solvent free preparation of N-substituted maleanilic acid

Novel Imides Amino Acids and Dipeptide Derivatives

Computer-Assisted Prediction of Favorable Substituents for High Bioactivity in Congeners

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