Studies on Bartonella Muris Anemia

Sandberg, Marta; Perla, David; Marmorston-Gottesman, J.

doi:10.1084/jem.57.1.81

Cited by 1 publication

(1 citation statement)

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“…In previous experiments (18) the changes in the concentration of certain chemical constituents of the blood in splenectomized rats of Bartonella carrier stock were found to be associated with Bartonella muris infection and anemia and were not due to the removal of the spleen itself. In rats free from this infection no change from the normal concentration in the blood constituents occurred.…”

Section: Discussionmentioning

confidence: 88%

The Metabolism of Copper and Iron in Splenectomized Rats Free From Bartonella Muris Infection

Sandberg¹,

Perla²

1934

Journal of Experimental Medicine

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In previous studies it was found that the chemical changes in the blood of splenectomized rats suffering from Bartonella muris anemia consist of an increase in the total fats and fatty acids, a drop in lecithin and total cholesterol, a rise in blood chloride concentration, a moderate acidosis, and a variable drop in blood sugar. The liver glycogen is almost depleted. These changes are attributable either to the severity of the anemia or to the infection. Blood chemistry studies on splenectomized rats that were not carriers of Bartonella muris and in which no infection or anemia occurred revealed no significant deviation from the normal. Splenectomy in the rat free from Bartonella rauris infection has no effect on metabolism that is demonstrable in the usual chemical analyses of the blood.The present studies were undertaken in order to determine the effect of splenectomy on the metabolism of copper and iron in the rat free from latent Bartonella muris infection.

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Section: Discussionmentioning

confidence: 88%