Studies on bacterial cellulose/poly(vinyl alcohol) hydrogel composites as tissue-engineered corneal stroma

Han, Yamei; Li, Cheng; Cai, Qingyun; Bao, Xiaorui; Tang, Liying; Ao, Haiyong; Liu, Jing; Jin, Mengyi; Yan, Zhou; Wan, Yizao; Liu, Zuguo

doi:10.1088/1748-605x/ab56ca

Cited by 32 publications

(24 citation statements)

References 50 publications

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“…The composite was not toxic against human corneal stroma cell lines with low levels of cytotoxicity. Furthermore, after 4 weeks, in vivo studies following intrastromal transplantation in rabbits showed that the corneas remained transparent with no inflammation or sensitisation and had increased revascularisation [62][63][64].…”

Section: Surgical Materialsmentioning

confidence: 96%

Recent Advances and Applications of Bacterial Cellulose in Biomedicine

et al. 2021

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Bacterial cellulose (BC) is an extracellular polymer produced by Komagateibacter xylinus, which has been shown to possess a multitude of properties, which makes it innately useful as a next-generation biopolymer. The structure of BC is comprised of glucose monomer units polymerised by cellulose synthase in β-1-4 glucan chains which form uniaxially orientated BC fibril bundles which measure 3–8 nm in diameter. BC is chemically identical to vegetal cellulose. However, when BC is compared with other natural or synthetic analogues, it shows a much higher performance in biomedical applications, potable treatment, nano-filters and functional applications. The main reason for this superiority is due to the high level of chemical purity, nano-fibrillar matrix and crystallinity. Upon using BC as a carrier or scaffold with other materials, unique and novel characteristics can be observed, which are all relatable to the features of BC. These properties, which include high tensile strength, high water holding capabilities and microfibrillar matrices, coupled with the overall physicochemical assets of bacterial cellulose makes it an ideal candidate for further scientific research into biopolymer development. This review thoroughly explores several areas in which BC is being investigated, ranging from biomedical applications to electronic applications, with a focus on the use as a next-generation wound dressing. The purpose of this review is to consolidate and discuss the most recent advancements in the applications of bacterial cellulose, primarily in biomedicine, but also in biotechnology.

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Section: Surgical Materialsmentioning

confidence: 96%

Recent Advances and Applications of Bacterial Cellulose in Biomedicine

et al. 2021

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“…Following administration of the eye drops and manual blinking of the murine eyes, the corneas were examined and imaged via slit-lamp microscopy to observe the hydrogel on the ocular surface. The process was performed as described previously [ 41 ].…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye

Han

Shi

et al. 2022

Bioactive Materials

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Dry eye is a common ocular disease that results in discomfort and impaired vision, impacting an individual's quality of life. A great number of drugs administered in eye drops to treat dry eye are poorly soluble in water and are rapidly eliminated from the ocular surface, which limits their therapeutic effects. Therefore, it is imperative to design a novel drug delivery system that not only improves the water solubility of the drug but also prolongs its retention time on the ocular surface. Herein, we develop a copolymer from mono-functional POSS, PEG, and PPG (MPOSS-PEG-PPG, MPEP) that exhibits temperature-sensitive sol-gel transition behavior. This thermo-responsive hydrogel improves the water solubility of FK506 and simultaneously provides a mucoadhesive, long-acting ocular delivery system. In addition, the FK506-loaded POSS hydrogel possesses good biocompatibility and significantly improves adhesion to the ocular surface. In comparison with other FK506 formulations and the PEG-PPG-FK506 (F127-FK506) hydrogel, this novel MPOSS-PEG-PPG-FK506 (MPEP-FK506) hydrogel is a more effective treatment of dry eye in the murine dry eye model. Therefore, delivery of FK506 in this POSS hydrogel has the potential to prolong drug retention time on the ocular surface, which will improve its therapeutic efficacy in the management of dry eye.

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“…Recent studies show that mechanical properties, including rigidity, stiffness, and elasticity, affect cell behavior, as well as their ability to adhere, proliferate, and differentiate [64]. The orientation of biomaterial fibers and their composition also have a significant impact on the biocompatibility, inflammation, neovascularization, and cell behavior on the scaffold [77,78].…”

Section: Re-epithelizationmentioning

confidence: 99%

Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration

et al. 2021

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Nowadays, tissue engineering is one of the most promising approaches for the regeneration of various tissues and organs, including the cornea. However, the inability of biomaterial scaffolds to successfully integrate into the environment of surrounding tissues is one of the main challenges that sufficiently limits the restoration of damaged corneal tissues. Thus, the modulation of molecular and cellular mechanisms is important and necessary for successful graft integration and long-term survival. The dynamics of molecular interactions affecting the site of injury will determine the corneal transplantation efficacy and the post-surgery clinical outcome. The interactions between biomaterial surfaces, cells and their microenvironment can regulate cell behavior and alter their physiology and signaling pathways. Nanotechnology is an advantageous tool for the current understanding, coordination, and directed regulation of molecular cell–transplant interactions on behalf of the healing of corneal wounds. Therefore, the use of various nanotechnological strategies will provide new solutions to the problem of corneal allograft rejection, by modulating and regulating host–graft interaction dynamics towards proper integration and long-term functionality of the transplant.

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Studies on bacterial cellulose/poly(vinyl alcohol) hydrogel composites as tissue-engineered corneal stroma

Cited by 32 publications

References 50 publications

Recent Advances and Applications of Bacterial Cellulose in Biomedicine

Recent Advances and Applications of Bacterial Cellulose in Biomedicine

Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye

Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration

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