Studies on Antiviral and Immuno-Regulation Activity of Low Molecular Weight Fucoidan from Laminaria japonica

Sun, Tao; Zhang, Xinhui; Miao, Ying; Zhou, Yang; Shi, Jie; Yan, Meixing; Chen, Anjin

doi:10.1007/s11802-018-3794-1

Cited by 30 publications

(29 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The effects on the phagocytic index and the phagocytic coefficient also increase with increasing dose. Moreover, LMWF can increase the half hemolysin value in middle and high doses [103]. Fucoidan isolated from Dndaria pinnatifida was shown to effective against HSV-1 by directly inhibiting viral replication and/or stimulating innate and adaptive immune defenses [104].…”

Section: Classical Activities Of Fucoidanmentioning

confidence: 99%

Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies

et al. 2019

View full text Add to dashboard Cite

The marine acid polysaccharide fucoidan has attracted attention from both the food and pharmaceutical industries due to its promising therapeutic effects. Fucoidan is a polysaccharide that mainly consists of L-fucose and sulphate groups. Its excellent biological function is attributed to its unique biological structure. Classical activities include antitumor, antioxidant, anticoagulant, antithrombotic, immunoregulatory, antiviral and anti-inflammatory effects. More recently, fucoidan has been shown to alleviate metabolic syndrome, protect the gastrointestinal tract, benefit angiogenesis and bone health. This review focuses on the progress in our understanding of the biological activities of fucoidan, highlighting its benefits for the treatment of human disease. We hope that this review can provide some theoretical basis and inspiration for the product development of fucoidan.

show abstract

Section: Classical Activities Of Fucoidanmentioning

confidence: 99%

Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In addition, intranasal administration of K. crassifolia fucoidan significantly improved survival and showed a decreased in the viral titers in IAV-infected mice. Sun et al [48] obtained two L. japonica LMWF fractions LF1 and LF2 by degradation, which contained fucose of 42.0% and 30.5%; galactose content of 19.8% and 23.9%; uronic acid content of 5.3% and 3.7%; and sulfate content of 30.7% and 32.5%, respectively. They found a weight-average Mw and number-average Mw to be 7600 and 7300 for LF1 and 3900 and 3700 for LF2, respectively.…”

Section: Therapeutic Potential Against Influenza a Virusmentioning

confidence: 99%

Therapeutic Effects of Fucoidan: A Review on Recent Studies

et al. 2019

View full text Add to dashboard Cite

Fucoidan is a polysaccharide largely made up of l-fucose and sulfate groups. Fucoidan is favorable worldwide, especially amongst the food and pharmaceutical industry as a consequence of its promising therapeutic effects. Its applaudable biological functions are ascribed to its unique biological structure. Classical bioactivities associated with fucoidan include anti-oxidant, anti-tumor, anti-coagulant, anti-thrombotic, immunoregulatory, anti-viral and anti-inflammatory effects. More recently, a variety of in vitro and in vivo studies have been carried out to further highlight its therapeutic potentials. This review focuses on the progress towards understanding fucoidan and its biological activities, which may be beneficial as a future therapy. Hence, we have summarized in vitro and in vivo studies that were done within the current decade. We expect this review and a variety of others can contribute as a theoretical basis for understanding and inspire further product development of fucoidan.

show abstract

“…Fucoidans have shown in vitro antiviral activity against HIV [ 20 , 21 , 22 ], HsV [ 23 , 24 , 25 , 26 , 27 , 28 ], Influenza virus [ 29 , 30 ], human cytomegalovirus [ 23 , 24 ], bovine viral diarrhea virus [ 31 , 32 , 33 ] and murine norovirus [ 34 ]. They prevent viral entry by competing for the attachment to positively charged envelope glycoproteins, in a process that is related to the level of sulphate groups present in the fucoidan [ 35 ].…”

Section: Polysaccharidesmentioning

confidence: 99%

Antiviral Potential of Algal Metabolites—A Comprehensive Review

et al. 2021

View full text Add to dashboard Cite

Historically, algae have stimulated significant economic interest particularly as a source of fertilizers, feeds, foods and pharmaceutical precursors. However, there is increasing interest in exploiting algal diversity for their antiviral potential. Here, we present an overview of 50-years of scientific and technological developments in the field of algae antivirals. After bibliometric analysis of 999 scientific references, a survey of 16 clinical trials and analysis of 84 patents, it was possible to identify the dominant algae, molecules and viruses that have been shaping and driving this promising field of research. A description of the most promising discoveries is presented according to molecule class. We observed a diverse range of algae and respective molecules displaying significant antiviral effects against an equally diverse range of viruses. Some natural algae molecules, like carrageenan, cyanovirin or griffithsin, are now considered prime reference molecules for their outstanding antiviral capacity. Crucially, while many algae antiviral applications have already reached successful commercialization, the large spectrum of algae antiviral capacities already identified suggests a strong potential for future expansion of this field.

show abstract

Studies on Antiviral and Immuno-Regulation Activity of Low Molecular Weight Fucoidan from Laminaria japonica

Cited by 30 publications

References 13 publications

Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies

Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies

Therapeutic Effects of Fucoidan: A Review on Recent Studies

Antiviral Potential of Algal Metabolites—A Comprehensive Review

Contact Info

Product

Resources

About