Studies on Antipyretic-Analgesic and Ulcerogenic Activity of Polyherbal Preparation in Rats and Mice

Gupta, Mradu; Shaw, Barnabas; Mukerjee, Alok

doi:10.3923/ijp.2008.88.94

Cited by 17 publications

(16 citation statements)

References 26 publications

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“…Polyphenols, flavonoids and tannins were reported to inhibit prostaglandin synthesis (Park et al 2001;Rajnarayana et al 2006;Gupta et al 2008Gupta et al , 2012Pan et al 2010). We consider that the presence of polyphenols and flavonoids in the crude extract and its polar fractions could be responsible of their antiinflammatory and analgesic activities.…”

Section: Discussionmentioning

confidence: 99%

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

Lajili

Deghrigue

Amor

et al. 2016

Pharmaceutical Biology

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Context: Red algae have been recognized as a rich natural source of compounds possessing interesting biological and pharmacological activities. Objective: This work investigates anti-inflammatory, analgesic and gastroprotective activities of MeOH/ CH 2 Cl 2 crude extract and its fractions F1 (50% MeOH) and F2 (80% MeOH) from the whole alga plant Laurencia obtusa Hudson (Rhodomelaceae). Materials and methods: Anti-inflammatory activity was evaluated in vitro using cytometric bead array (CBA) technology to follow up the secretion of tumour necrosis factor alpha (TNF-a) in lipopolysaccharide activated THP-1 monocytic cells at doses of 10-250 lg/mL and in vivo using carrageenan-induced paw oedema in Wistar rats at doses of 25, 50, 100 and 200 mg/kg. Crude extract and fractions were tested at the doses of 25, 50, 100 and 200 mg/kg for peripheral and central analgesic activity by acetic acid-induced writhing test and hot-plate method, respectively, in Swiss albino mice. Gastroprotective activity was evaluated using HCl/ethanol-induced gastric ulcer test in rats at doses of 25, 50, 100 and 200 mg/kg. Results: Crude extract, F1 and F2 showed an interesting inhibition of TNF-a secretion with IC 50 values of 25, 52 and 24 lg/mL, respectively, and a significant anti-inflammatory activity in vivo (p < 0.01), 3 h after carrageenan injection, the oedema inhibition was 55.37%, 52.18% and 62.86%, respectively, at the dose of 100 mg/kg. Furthermore, they showed a significant peripheral analgesic activity with 53.79%, 55.92% and 57.37% (p < 0.01) of writhing inhibition, respectively. However, no significant activity was found in the hotplate test. An interesting gastroprotective effect was observed with crude extract and its fractions F1 and F2 with a gastric ulcer inhibition of 65.48%, 77.42% and 81.29%, respectively, at the dose of 50 mg/kg. Discussion and conclusion: These results suggest that L. obtusa might be used as a potential source of natural anti-inflammatory and analgesic agents with gastroprotective effect. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

Lajili

Deghrigue

Amor

et al. 2016

Pharmaceutical Biology

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“…The antipyretic effect of different plant species could be attributed to the presence of flavonoids since flavonoids normally exhibit antipyretic, analgesic and antiinflammatory properties [33][34][35][36] . The acetone extract of the seeds of S. asoca contains different phytoconstituents including high amounts of flavonoids and tannins.…”

Section: Discussionmentioning

confidence: 99%

Pharmacognostical, phytochemical and pharmacological evaluation for the antipyretic effect of the seeds of Saraca asoca Roxb.

Sasmal¹,

Majumdar²,

Gupta³

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…The overall central analgesic effect of the test drug even at higher dose was a little lower than the standard drug morphine. The significant analgesic effect at the higher dose was attributed to the presence of high concentration of flavonoidic compounds which inhibited the synthesis, release or receptor responses in prostaglandin mediated effects (Gupta et al, 2008;Pan et al, 2010;Gupta et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…The standard procedure prescribed by Veerappan et al (2005) was used for observing the abdominal constriction writhings resulting from intraperitoneal injection of acetic acid (10 ml/kg of 0.6% v/v glacial acetic acid solution in water) (Gupta et al, 2008). Saline (10 ml/kg) was orally administered to group A (control group) whereas standard aspirin (100 mg/kg) was prescribed for group B and 300 and 500 mg/kg test drug extract was orally administered to groups C and D, respectively.…”

Section: The Assessment Of Peripheral Analgesic Effectmentioning

confidence: 99%

Evaluation of analgesic, antipyretic and anti-inflammatory effects of methanol extract of traditional herbal medicine using rodents

Gupta¹,

Banerjee²,

Mukherjee³

2013

J. Pharmacognosy Phytother.

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The analgesic, antipyretic and anti-inflammatory effects of methanol extract of botanical medicine prepared by taking equal amounts of dried stems of Tinospora cordifolia Willd, fruits of Emblica officinalis Gaertn and rhizomes of Cyperus rotundus Linn were evaluated using standard methods. These botanicals have been traditionally used in Indian system of medicine for treatment of fever, joint pain, body ache and muscular pain in the form of single or combined drug therapy. After acute toxicity studies, anti-inflammatory effect was assessed using carrageen induced paw oedema test and antipyretic effect using yeast induced pyrexia method. Tail immersion, hot plate and writhings test were used for determining the analgesic properties. Phytochemical analysis revealed the presence of polyphenolic flavonoids, tannin and saponins. Significant anti-inflammatory, antipyretic and analgesic properties were noticed in dose dependant manner after methanolic extract administration, especially at 500 mg/kg dose. These test drug activities were sustained and comparable to the standard drugs while exhibiting no acute toxicity. The findings indicate that the methanolic extract possesses significantly high anti-inflammatory, antipyretic and analgesic properties without any acute toxicity possibly due to the presence of flavonoids.

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Studies on Antipyretic-Analgesic and Ulcerogenic Activity of Polyherbal Preparation in Rats and Mice

Cited by 17 publications

References 26 publications

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

Pharmacognostical, phytochemical and pharmacological evaluation for the antipyretic effect of the seeds of Saraca asoca Roxb.

Evaluation of analgesic, antipyretic and anti-inflammatory effects of methanol extract of traditional herbal medicine using rodents

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