Studies on Antimicrobial Evaluation of Some 1-((1-(1H-Benzo[d]imidazol-2-yl)ethylidene)amino)-6-((arylidene)amino)-2-oxo-4-phenyl-1, 2-dihydropyridine-3,5-dicarbonitriles

Synthesis and Characterization of Some Novel Coumarin Based 2-Pyridone Heterocycles with their Broad Spectrum Antimicrobial Potency

“…Moreover, 2-pyridones are a class of newly exposed potent antibacterial agents that are of specific concern due to their in vitro and in vivo antibacterial potencies against the bacterial type II DNA topoisomerases, which consist of two highly homologous enzymes-DNA gyrase and topoisomerase IV [22,23]. In accordance with our previous work [24,25,26] Online: 2016-05-30…”

Synthesis and Characterization of Some Novel Coumarin Based 2-Pyridone Heterocycles with their Broad Spectrum Antimicrobial Potency

“…Moreover, 2-pyridones are a class of newly exposed potent antibacterial agents that are of specific concern due to their in vitro and in vivo antibacterial potencies against the bacterial type II DNA topoisomerases, which consist of two highly homologous enzymes-DNA gyrase and topoisomerase IV [22,23]. In accordance with our previous work [24,25,26] and medicinal importance of coumarin and 2-pyridone motifs we report herein the synthesis of a new class of 6-((arylidene)amino)-2-oxo-1-((1-(2-oxo-2H-chromen-3-yl)ethylidene)amino)-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitriles 4a-o as potential antimicrobial agents.…”

Approach for the Synthesis of Potent Antimicrobials Containing Pyrazole, Pyrimidine and Morpholine Analogues

“…1). In accordance with our previous work [16][17][18] and medicinal significance of pyrazole, pyrimidine and morpholine motifs, we decided to combine all these moieties in to one single frame with hybrid approach as potential antimicrobial agents.…”