Abstract:A series of cobalt(III) mixed ligand complexes of type [Co(en)2L]+3, where L is bipyridine, 1,10-phenanthroline, imidazole, methylimidazole, ethyleimidazole, dimethylimidazole, urea, thiourea, acetamide, thioacetamide, semicarbazide, thiosemicarbazide, or pyrazole, have been isolated and characterized. The structural elucidation of these complexes has been explored by using absorption, infrared, and 1H NMR nuclear magnetic resonance spectral methods. The infrared spectral data of all these complexes exhibit a … Show more
“…Hence, the absorbance increases sharply as the helix melts and the DNA strands separate. 52 Stabilization of the helix because of the intercalation of probes results in an increase in the helix melting temperature of the DNA. 35,45 On the contrary, groove binding leads to an inappreciable change in the T m value.…”
Section: Circular Dichroism and Helix Melting Studymentioning
“…Hence, the absorbance increases sharply as the helix melts and the DNA strands separate. 52 Stabilization of the helix because of the intercalation of probes results in an increase in the helix melting temperature of the DNA. 35,45 On the contrary, groove binding leads to an inappreciable change in the T m value.…”
Section: Circular Dichroism and Helix Melting Studymentioning
“…The ability of Co(III) complexes to mediate DNA cleavage has been well documented [35,40]. The effects of the complex [Co 2 L 2 ] 2+ on supercoiled DNA were studied using plasmid pUC18 in solution (Fig.…”
“…Rapid development of resistance is another factor that hampers the identification of novel antibiotics generally, and that is something that also cannot be avoided with DNAbinding compounds. After all, the short generation time of some bacteria (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) minutes) provides plenty of scope for acquiring resistance genes or mutations that lead to resistance, in particular when that is compared to the speed at which novel antibiotics are introduced into the market (years). Expanding our arsenal with novel antimicrobials with barely utilised cellular targets may help us to stay ahead and prevent entering into a post-antibiotic era.…”
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