Studies on Antilymphocyte Serum and Transplantation Immunity in Syrian Hamsters

Cf, Shaffer; Jw, Streilein; Ps, Freedberg; Sherman, J.D.

doi:10.1097/00007890-197104000-00007

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1972

1976

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“…It can be sufficiently effective to allow skin xenografts to survive during the period of ATS treatment (Shaffer et al, 1971). Thymectomy is said to enhance the immunosuppressive effect of antilymphocyte serum (ALS) in both skin and tumour xenografts (Davis and Lewis, 1967;Jeejeebhoy, 1970;Phillips and Gazet, 1970).…”

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confidence: 99%

Metastatic Spread of Human Tumour Implanted into Thymectomized, Antithymocyte Serum Treated Hamsters

Cobb¹

1972

Br J Cancer

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Summary.-The growth and metastatic spread of human tumours in immunosuppressed hamsters is described. A variety of human tumours were transplanted to the flank or the cheek pouch of the hamsters. Immunosuppression was obtained by combined thymectomy and ATS treatment. In the period up to 4 months after implantation, metastases to the lungs were observed with carcinomata of breast, colon, larynx and kidney; also melanoma, rhabdomyosarcoma, fibrosarcoma and teratoma of testis. Fourteen of 20 different tumours implanted metastasized to the lungs. Only 2 tumours, a hypernephroma and a melanoma, became established at the site of implantation; the remainder regressed even though the tumour was proliferating in the lungs.

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confidence: 99%