Studies on antidiarrhoeal activity of Jatropha curcus root extract in albino mice

Mujumdar, A. M.; Upadhye, Anuradha S.; Misar, Ashwini

doi:10.1016/s0378-8741(99)00167-1

Cited by 43 publications

(22 citation statements)

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“…On the contrary, density of wood for the belowground category had a lesser density 0.26 g cm -1 compared with the branch (0.36 g cm -1 ) and twig (0.48 g cm -1 ). Mujumdar et al (2000) and Krishnamurthy et al (2012) found jatropha roots had a well-defined cortex of which large parenchymatous cells arranged Total fruit biomass (g) Fig. 1 Relationship between length of fruit-bearing twig with diameter and total fruit biomass; vertical lines in-between fruit biomass show upper and lower limits for diameter boundary determination used for the FBA model; the sloping line relating the length of fruit-bearing twig to diameter indicates a proportionality factor centripetally that were mostly for water storage and had xylem vessels with assorted sizes, but did not have xylem fibres.…”

Section: Tree Parametersmentioning

confidence: 99%

Tree or shrub: a functional branch analysis of Jatropha curcas L.

Tjeuw¹,

Mulia²,

Slingerland³

et al. 2015

Agroforest Syst

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Jatropha curcas is an oil-bearing semievergreen shrub or small tree with potential as a source of sustainable biofuel, yet information regarding vegetative and fruit biomass in relation to plant architecture is lacking. Research conducted in Indonesia used the tree based functional branch analysis (FBA) model as a non-destructive method to estimate above and belowground biomass, and plant architecture. The FBA utility for shrubs was unknown and required modification. This research used destructive measurements to validate modifications to the FBA model that included subcategorisation of the tapering coefficient for twig, branch, and wood diameter classes, and addition of a fruit load parameter in the distal link. The modified FBA model confirmed jatropha to be a shrub rather than a tree, producing variable estimates for aboveground biomass. This variation was due to morphological plasticity in the length-diameter relationship of the branches that diverged from fractal branching architecture. Fruit biomass variation between replicates was not well estimated and total proximal root diameter was a poor predictor of total root biomass, due to the proximal roots having enlarged water storage structures that do not follow fractal branching assumptions. Jatropha fruit was shown to predominate on twigs with a diameter between 0.9 and 1.4 cm. Understanding the correlation between fruit development and plant architecture will be necessary for fine-tuning the FBA model for future commercial breeding and selection. The high degree of morphological plasticity displayed by jatropha requires consideration when determining plant biomass.

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Section: Tree Parametersmentioning

confidence: 99%

Tree or shrub: a functional branch analysis of Jatropha curcas L.

Tjeuw¹,

Mulia²,

Slingerland³

et al. 2015

Agroforest Syst

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“…The plant juice is a purgative. Root bark is used in rheumatism and fruit is anthelmintic (Baral & Kurmi 2006 Root extract is antidiarrheal (Mujumdar et al 2000). Root paste is anti-inflammatory (Mujumdar & Misar 2004).…”

Section: Eclipta False Daisy (E)mentioning

confidence: 99%

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Kunwar

Uprety

Burlakoti

et al. 2009

Ethnobot. Res. App.

318

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Ethnopharmacological knowledge is common and import among tribal populations but much of the information is empirical at best lacking scientific validation. Despite widespread use of plant resources in traditional medicines, bioassay analysis of very few plant species have been conducted to investigate their medicinal properties, and to ascertain safety and efficacy of traditional remedies. The present study analyses indigenous uses of medicinal plants of far-west Nepal and compares with earlier ayurveda studies, phytochemical assessments and pharmacological actions. A field study was carried out in Baitadi and Darchula districts of far-west Nepal. Group discussions, informal meetings, questionnaire surveys and field observations were employed for primary data collection. Voucher specimens were collected with field notes and codes and deposited at Tribhuvan University Central Herbarium (TUCH), Kathmandu. Only 50% of species surveyed shared common uses with ayurvedic medicine. This implies that these herbal remedies are part of an independent health care system in the Nepal Himalaya, which is indigenous and influenced by ayurveda. The folk uses of some of the species were contradicting to those of ayurveda and phytochemical bioassays. A detailed phytochemical study on those species would be an important line of research. IntroductionMedicinal plants help in alleviating human suffering and are widely used for subsistence, home remedies, and trade (Kunwar et al. 2006). It is estimated that 70-80% of people worldwide rely on traditional herbal medicine to meet their primary health care needs (Farnsworth & Soejarto 1991). The ayurveda is an ancient traditional system of medicine with remedies for health and alleviation of illness. The acceptance of the ayurveda is gearing up and use of indigenous drugs of natural/plant origin is a maPublished: January 16, 2009 Ethnobotany Research & Applications 6www.ethnobotanyjournal.org/vol7/i1547-3465-07-005.pdf cuna pruriens (L.) DC. for Parkinson's disease, Commiphora as a hypolipidemic, Asclepias as cardiotonic, psoralens for vitiligo, curcumines for inflammation, baccoside for mental retention, picrosides for hepatoprotective, diosgenin for the synthesis of steroidal hormones, guggulsterons as hypolipidemic, piperidine as bioavailability enhancers, asarone as hallucinogenic, phyllanthins as anti-virals, withanolides and many other steroidal lactones and their glycosides as immunomodulators (Jain 1994, Patwardhan 2000. As an example, the sale of drugs derived from the plant Taxus The increasing use of traditional therapies demands more scientifically sound evidence for the principles behind therapies and for effectiveness of medicines (Patwardhan et al. 2005). The therapies are often criticized due to dearth of research, critical evaluation, in vivo studies and validations (Fong 2002, Houghton 1995 to support the safety of uses. At the same time, ethnopharmacological knowledge is percolating down these days among the tribal population. The present study, therefore aim...

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“…Some of these traditional uses appear to be supported by data provided by pharmacological studies. For example, the methanol extract of Jatropha curcas L. was shown to possess activity against castor oil induced diarrhea and to reduce gastrointestinal motility after charcoal meal administration in albino mice (Mujumdar et al, 2000). In addition, the ethanolic extract of J. gossypiifolia can elicit hypotension in conscious normotensive rats when given by oral route, and has vasorelaxant activity in rat mesenteric rings precontracted with norepinephrine (NE) or Ca 2+ (Abreu et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Antispasmodic effect of Jatropha gossypiifolia is mediated through dual blockade of muscarinic receptors and Ca2+ channels

Silva¹,

Abreu²,

Freire³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The antispasmodic activity of Jatropha gossypiifolia L., Euphorbiaceae, aerial parts was investigated in rodents using the mouse intestinal transit model and acetylcholine (ACh, to 10 -4 M) and calcium (CaCl 2 , 10 -4 to 10 -1 M)-induced contractions of isolated rat jejunum. Similar to atropine (1 mg/kg), oral doses of ethanolic extract (EE) of J. gossypiifolia (500, 1000 and 2000 mg/kg) produced a decrease in intestinal transit (37.6 to 57.1%) when compared with control. The ACh-induced contraction in the jejunum was inhibited by EE (0.5, 1.0 and 2.0 mg/ mL), chloroformic (CF) and aqueous fractions (0.1 and 0.5 mg/mL) and methanolic subfraction (0.05 and 0.25 mg/mL), suggesting an antimuscarinic mechanism. CaCl 2 -induced responses in jejunum were also attenuated in the presence of CF (0.05 and 0.1 mg/mL) implying a direct interference of CF with the influx of calcium ions in the cells. Only the organic fraction of the extract had a calcium-antagonist effect, whereas both chloroformic and aqueous fractions had anticholinergic effect. These results suggest that the antispasmodic effect of J. gossypiifolia may be due a combination of anticholinergic and calcium antagonist mechanisms.

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Studies on antidiarrhoeal activity of Jatropha curcus root extract in albino mice

Cited by 43 publications

References 5 publications

Tree or shrub: a functional branch analysis of Jatropha curcas L.

Tree or shrub: a functional branch analysis of Jatropha curcas L.

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Antispasmodic effect of Jatropha gossypiifolia is mediated through dual blockade of muscarinic receptors and Ca2+ channels

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