Studies on anticoagulants. X. An attempt to explain the difference in anticoagulant activity between dicoumarol and some of its derivatives

Synthesis and Anti-inflammatory Activity of Novel Furochromenes

“…1 4-Hydroxycoumarin was determined as a building unit of natural product dicoumarol, isolated from spoiled sweet clover and identified as a causative agent of haemorrhagic cattle deaths. 2 The intensive investigations of many natural and synthetic coumarins resulted in discovery of warfarin and other 3-alkyl-4-hydroxycoumarins as potent, clinically used anticoagulants, [3][4][5][6][7][8] mainly used in postsurgical prevention of wound induced thrombus formation. Intensive investigation on the molecular level of action of these compounds showed that they prevent reduction of vitamin K epoxide to active vitamin K thus inhibiting the biosynthesis of protrombin and other clothing factors.…”