Studies on anti-inflammatory, antipyretic and analgesic properties of Caesalpinia bonducella F. seed oil in experimental animal models

Shukla̽, Shruti; Mehta, Archana; Mehta, P.; Vyas, Suresh P.; Shukla, Satish; Bajpai, Vivek K.

doi:10.1016/j.fct.2009.09.015

Cited by 86 publications

(60 citation statements)

References 6 publications

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“…20 It has been reported to have antiinflammatory, antipyretic, analgesic, antioxidant, antibacterial, antifilarial, antiasthamatic, antitumor, anxiolytic 18 , immunomodulatory and hepatoprotective properties. [21][22][23][24][25] Some other study reports also confirmed the hypolipidemic action of the seed extract and additional benefits in the diabetic condition. Apart from that there are some reports showing hypoglycemic and antidiabetic activity of the extracts of its seeds kernel.…”

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confidence: 52%

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2016

IJPSR

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Evidence implicates hyperglycemia induced oxidative stress as a key factor in the pathogenesis of both microvascular and macrovascular complications in the body. Our main objective behind this study was to explore the beneficial effect of Caesalpinia bonducella seed kernel extract on Streptozotocin-induced hyperglycaemia and oxidative damage in rats. Rats were made hyperglycemic by single intravenous injection of Streptozotocin 40mg/kg of body weight. Hyperglycemic rats treated with extract in three different doses of 200, 400 and 600 mg/kg of body weight orally for 21 days shows a significant decrease in blood glucose, HbA1c, free amino groups whereas an increase in serum insulin level, liver glycogen contents with a significant improvement in glucose tolerance. Furthermore, above extract supplementation significantly decreases the pancreatic thiobarbituric acid-reactive substances levels along with an increase in superoxide dismutase, catalase and glutathione contents in pancreatic tissues in treatment groups when compared with control hyperglycemic rats. Treatment with above extract has lessened the severities of degenerative changes in pancreas and also in the liver tissues as compared to that of untreated control rat with hyperglycemia. Our results suggest that the ethanolic extract of Caesalpinia bonducella seed kernel improves the antioxidant defense under hyperglycemic condition and also exhibit strong anti-hyperglycaemic effect in dose dependent manner.

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confidence: 52%

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2016

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“…The antipyretic activity of methanolic stem bark extracts of K. africana and A. hockii could be due to the ability of herbal preparations to possess a wealth of secondary metabolites required in the management of various diseases and disorders [19]. The qualitative phytochemical screening of methanolic stem bark extracts of A. hockii and K. africana indicated the presence of alkaloids, flavonoids, steroids, saponins and terpenoids (Table 4).…”

Section: Discussionmentioning

confidence: 99%

“…Herbal preparations possess a wealthy of secondary metabolites that can manage various disease and disorders. In addition, herbal preparations have shown potent antipyretic activities in experimental animals [19].…”

Section: Discussionmentioning

confidence: 99%

Antipyretic Properties of Methanol Stem Bark Extracts of Acacia hockii De Wild and Kigelia africana (Lam) Benth in Wistar Rats

JK¹,

PM²

2016

J Pharmacogn Nat Prod

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“…It was observed that the action was dependent on proportion of doses. The seed oil of C. bonducella is good source for analgesic and anti-inflammatory agent 9,30 .…”

Section: Analgesic and Anti-inflammatory Activitiesmentioning

confidence: 99%

Phytochemical and Pharmacological Review of Caesalpinia Bonducella

Kakade¹,

Pingale²,

Chaskar³

2017

Int. Res. J. Pharm.

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Caesalpinia bonducella is classified under the family of Caesalpiniaceae. It is also known as C. bonducella Flem and C. crista Linn. The plant is found in the tropical and the subtropical parts of Asia. It is also found in Andaman, Nicobar islands and in all over India. The plant is a large prickly shrub. The branches are finely gray downy armed with hooked and hard prickles. Leaves, seeds, roots and bark of this plant are useful parts as a medicine. Caesalpinia bonducella (roxb.) shows antipyretic, anti-inflammatory, anthelmintic, antimalarial, antioxidant, antibacterial, antitumor and antidiabetic activities. The Phytochemical screening of C.bonducella shows the existence of different bioactive compounds like sterols,

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Studies on anti-inflammatory, antipyretic and analgesic properties of Caesalpinia bonducella F. seed oil in experimental animal models

Cited by 86 publications

References 6 publications

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Antipyretic Properties of Methanol Stem Bark Extracts of Acacia hockii De Wild and Kigelia africana (Lam) Benth in Wistar Rats

Phytochemical and Pharmacological Review of Caesalpinia Bonducella

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