Studies on anti-inflammatory agents. V. A new anti-inflammatory constituent of Pyracantha crenulata Roem.

Plant use in the medicinal practices known as “strict diets” in Chazuta valley (Peruvian Amazon)

“…One of them (i.e. pyracrenic acid) has shown antinflammatory activity (Otsuka et al, 1981a). Lup-20(29)-en triterpenoids from other plants, have shown antimicrobial activity (Kuroyanagi et al, 1985;Mustafa et al, 2000;Woldemichael et al, 2004).…”

Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: Chemistry, biological evaluations, and therapeutic prospects

“…The wide range of biological properties linked to betulinic acid have recently been recapitulated and analyzed in three excellent revues. [211][212][213] Several hemisynthesis of 28 starting from betulin via betulonic acid [214][215][216][217] or from various naturally occuring betulinic acid derivatives such as glycosides, [218][219][220][221] sulfates, 222 or dihydroxycinnamic esters 223 have been reported. To our knowledge, only one naturally occuring APN inhibitor originates from animal kingdom:…”

Bioactive Lupane and Hopane Triterpenes from Lepisanthes senegalensis

“…Eight known compounds (5-12) were identified by comparison of spectroscopic data and physical data with those reported in literature to be 3-O-trans-caffeoylbetulin (5) [5], 3-O-trans-caffeoylbetulinic acid (6) [8], betulin (7) [9], betulinic acid (8) [10], lupeol (9) [11], stigmasterol (10) [12], 2,6-dimethoxy-1,4-benzoquinone (11) [13], and 3-O-trans-caffeoyllupeol (12) [14].…”

“…Compounds 1-6 and 12 were evaluated for antimalarial activity against chloroquine resistant Plasmodium falciparum and cytotoxicity against KB, NCI-H187, and Vero cell (▶ Table 2). Among these only 6 exhibited strong antimalarial activity with an IC 50 val-▶ (5)(6)(7)(8)(9)(10)(11)(12). Their structures were established on the basis of spectroscopic techniques as well as single-crystal X-ray diffraction analysis.…”