Studies on amino acid composition of renal glomeruli from the diabetics.

Sato, Tokutaro; Oguma, S; Yoshinaga, Kaoru

doi:10.1620/tjem.147.89

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…Beisswenger and Spiro" also observed a small decrease in the lysine content of glomerular basement membrane and a corresponding increase in hydroxylysine and in hydroxylysine-linked glycosyl-galactosyl disaccharide units. While its, 11,145,223,258,261 investigator^'^^^^^^,^^^ reported that the sialic acid content and half-cystine content of diabetic glomerular basement membranes were significantly decreased, changes not observed by Beisswenger and Spiro." While De Bats et al55 confirmed the changes in lysine, hydroxylysine, and hydroxylysine-disaccharide units observed by Beisswenger and Spiro," they also observed a decrease in sialic acid content with no change in half-cystine.…”

Section: Basement Membrane Changes In Diabetesmentioning

confidence: 99%

Basement membrane abnormalities in diabetes mellitus: Relationship to clinical microangiopathy

Williamson

Tilton

Chang

et al. 1988

Diabetes Metab. Rev.

103

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Section: Basement Membrane Changes In Diabetesmentioning

confidence: 99%

Basement membrane abnormalities in diabetes mellitus: Relationship to clinical microangiopathy

Williamson

Tilton

Chang

et al. 1988

Diabetes Metab. Rev.

103

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Age-related changes in glomerular volume and hydroxyproline content in rat and human.

Cortés¹,

Zhao²,

Dumler³

et al. 1992

Journal of the American Society of Nephrology

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Total 4-hydroxyproline content and volume were measured in the same sample of microdissected glomeruli obtained fro rat and human outer or inner cortex. Glomerular volume was determined by computer-assisted image analysis, and 4-hydroxyproline was measured by a highly sensitive gas-liquid chromatographic method. Results were expressed as weight of basement membrane material by comparison with the amount of 4-hydroxyproline in purified basement membrane/mesangial matrix preparations. Microanalyses were possible in samples containing as few as eight human glomeruli. Rat glomerular size increased sevenfold between 5 wk and 2 yr of age, with volume being consistently 36 to 45% greater in inner than in outer cortex glomeruli. Basement membrane material content per glomerulus markedly increased with age (12-fold); however, when expressed per unit volume, this change was greatly reduced (2-fold). Expressed per volume, inner and outer cortex glomerular content of basement membrane material was always similar, regardless of age. Therefore, a greater glomerular size, in itself, does not accelerate the rate of basement membrane material deposition. Glomerular size distributions (measured by skewness and kurtosis) did not change, indicating that, although glomerular volume increases with age, aging does not appear to cause the emergence of distinct glomerular populations within an age group. Basement membrane material accumulation is probably a generalized change. Human glomeruli increased sevenfold in size from infancy to adulthood and then declined during senescence. Contrary to that in the rat, glomerular basement membrane material content appeared to closely follow size changes, thus, varying little from infancy to senescence if expressed per unit of glomerular volume.

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Studies on amino acid composition of renal glomeruli from the diabetics.

Cited by 2 publications

References 13 publications

Basement membrane abnormalities in diabetes mellitus: Relationship to clinical microangiopathy

Basement membrane abnormalities in diabetes mellitus: Relationship to clinical microangiopathy

Age-related changes in glomerular volume and hydroxyproline content in rat and human.

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