Studies on Ameboid Motion and Secretion of Motor End Plates

Carey, Eben J.; Massopust, Leo C.; Zeit, Walter; Haushalter, Eugene; Schmitz, J. A.

doi:10.1097/00005072-194504000-00003

Cited by 5 publications

(3 citation statements)

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“…The muscle lesions in the immature mice may be similar to those described in monkey and human poliomyelitis by Carey and his colleagues (15,16) and in man by Dublin, Bede, and Brown (17). These authors paid particular attention to the terminal nerve structures but Carey et al described degeneration of the muscle fibers, including loss of striations and hyalin changes, and Dublin reported atrophy of the muscle fibers ending in dark, pyknotic masses.…”

Section: Discussionsupporting

confidence: 63%

A Virus Recovered From the Feces of "Poliomyelitis" Patients Pathogenic for Suckling Mice

Dalldorf

Sickles

Plager

et al. 1949

Journal of Experimental Medicine

110

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The present report describes the isolation and certain properties of a virus recovered from the feces of children having symptoms similar to those of poliomyelitis. The agent differs from poliomyelitis virus in its host range, being pathogenic for suckling mice and hamsters but not for adult mice or hamsters or for rhesus monkeys. The disease in the experimental animal differs from poliomyelitis in that the anatomical response is in the striated muscles rather than the central nervous system (1).The study was undertaken in 1947 and the original plan was to test fecal suspensions in mice and hamsters from a number of outbreaks. The work was prompted by the report of Milzer and Byrd (2) that autolyzed brain suspension facilitates the isolation of poliomyelitis virus in mice, and by certain unpublished observations of the Battle Hill epidemic of poliomyelitis, which implied that such isolations might be possible. Hamsters were included because of their value in the Battle Hill work (3). After many specimens had been tested without success, it was decided to add an additional group of test animals, suckling mice. This was done because other studies in the Division had suggested that such animals are unusually susceptible, under certain circumstances, to the OT strain of mouse encephalomyelitis virus. Nature of the SpecimensPoliomyelitis was not epidemic in up-state New York in 1947 and only 925 cases were reported to the Department of Health. Thirty (3.2 per cent) of these died. The non-paralytic cases amounted to 42.6 per cent. Twenty per cent of the patients were more than 20 years of age. The disease did not differ significantly in these respects from that in the 2 preceding years or in 1948.The specimens were collected by district state health officers from five small outbreaks in widely separated parts of New York State. One or more fecal and blood samples were received from forty-two individuals, of whom fourteen were patients and twenty-eight were contacts. MetkodsThe blood was mailed to the central laboratory in the usual fashion. The feces were brought directly to us by messenger or shipped in iced containers. When received, the feces 567 on

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Section: Discussionsupporting

confidence: 63%

A Virus Recovered From the Feces of "Poliomyelitis" Patients Pathogenic for Suckling Mice

Dalldorf

Sickles

Plager

et al. 1949

Journal of Experimental Medicine

110

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“…Despite this fundamental difficulty Carey and his associates were able to describe the production of characteristic changes in myoneural junctions by many different ways-by electrical shocks and the inhalation of carbon dioxide (Carey, 1941a and 3, 1942), by the action of a number of drugs, including curare, quinine, physostigmine and acetylcholine (Carey, 1 9 4 4~) and D.D.T. (Carey et al, 1946a), by the injection of lactic acid (Carey and Massopust, 1944), in human poliomyelitis (Carey et aZ., 1944a) and in experimental poliomyelitis in monkeys (Carey, 1943 ;Carey, 1944b), following hzmorrhagic shock (Carey et al, 19446), traumatic shock (Carey et al., 1945a, Carey et al, 19456) and thermal shock (Carey et al, 19463), after nerve section (Carey et al, 1946c), and after disuse (Carey et al, 1948). This formidable series of papers is characterised by beautiful illustrations and many novel views on the structure and particularly the function of nerve and muscle.…”

Section: Discussionmentioning

confidence: 99%

“…Again, the granules of Kuhne are frequently present in gold preparations, but only rarely in methylene blue preparations ( fig. 13) and never in silver preparations, although Carey (1944a) has implied that their counterpart in silver preparations is that capricious and controversial structure the periterminal network. The problem of comparing the results obtained by the different methods is avoided to some extent in this paper by considering separately the results obtained with each method in turn.…”

Section: Fmentioning

confidence: 99%

Myoneural junctions and toxic agents

Denz

1951

J. Pathol.

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Physiology of Botulinus Toxin

Guyton¹

1947

Arch NeurPsych

110

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cated that its action is chiefly on the peripheral rather than the central nervous system.1 It has also been shown that the nerve trunk and muscle probably are not involved in the poisoning.2 By a process of elimination it has therefore been reasoned that poisoning occurs at the myoneural junction. On the basis of pathologic studies, however, effects of botulinus toxin on the central nervous system have been described, but there is little agreement among the various reports.3 Moreover, action of the toxin has been compared to that of curare because the two substances act at approximately the same point in the peripheral nervous system.1b This idea has persisted strongly; but, as will be shown later, it appears to be without foundation.It has been the purpose of the present investigation to obtain additional evidence for localizing the action of botulinus toxin and to investigate the equally important question of the manner in which the toxin produces its effects. Throughout this study, all experiments have been made with type A botulinus toxin, in distinction to the other types.From additional limited experience with types B, C and E toxin, there is no reason to believe that the different types of toxin vary in their action except in their rate of absorption, in speed of destruction in the body and in quantity necessary to produce poisoning.

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Studies on Ameboid Motion and Secretion of Motor End Plates

Cited by 5 publications

References 0 publications

A Virus Recovered From the Feces of "Poliomyelitis" Patients Pathogenic for Suckling Mice

A Virus Recovered From the Feces of "Poliomyelitis" Patients Pathogenic for Suckling Mice

Myoneural junctions and toxic agents

Physiology of Botulinus Toxin

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