Studies on alkylheteroaromatic compounds. The reactivity of alkyl polyfunctionally substituted azines towards electrophilic reagents

An aminoimidazole and its utility in heterocyclic synthesis

“…This product is assumed to be formed via addition of the amino group in 4 to the double bond in 10 to yield a Michael adduct 11, which then cyclizes and autoxidizes to 12. Similar autoxidation has been previously reported [22,23]. Compound 503 SCHEME 1 12 could also be obtained via reaction of 4 with benzaldehyde and subsequent addition of malononitrile to the so-formed Schiff's base derivative 13.…”

Chitosan as heterogeneous catalyst in Michael additions: The reaction of cinnamonitriles with active methyls, active methylenes and phenols

“…1 Since then plenty of acyclic active methylenes, [2][3][4][5] cyclic active methylenes, 6-7 functionally substituted alkylazoles, [8][9][10][11] alkylazinylcarbonitriles [12][13] as well as other nucleophilic reagents have been added during the 1970's and 1980's. [14][15][16][17][18] Generally, reactions of benzylidene-malononitrile with active methylene ketones give aminopyrancarbonitriles.…”

Synthesis of Some New 6,8‐Disubstituted 7,8‐Dihydropyrimido[2,3:4,3]pyrazolo[1,5‐a]pyrimidines and 6,7,8‐Trisubstituted Pyrimido[2,3:4,3]Pyrazolo[1,5‐a]Pyrimidine Derivatives

“…24 The reaction of thioxopyrimidine 4 with excess of 85% hydrazine hydrate in refluxing ethanol for 24 h gave the corresponding 3-amino-4-methyl-6-phenylpyrazolo [3,4-d]pyrimidine 5 (Scheme I). The structure of 5 was established by examining spectral data and elemental analysis.…”