Studies on adsorption characteristics and mechanism of adsorption of chlorhexidine mainly by carbon black

Akaho, Eiichi; Fukumori, Yoshinobu

doi:10.1002/jps.1081

Cited by 13 publications

(11 citation statements)

References 24 publications

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“…Salicylic acid and minocycline31, 38 will be partially deprotonated in PBS (pH 7.4), whereas chlorhexidine and clindamycin will be mostly in the neutral form. Chlorhexidine has a higher pKa value (10.3)31, 39 and clindamycin is also basic with a pKa value of 7.6,31, 40 thus, both will be mostly neutral at the pH of these experiments 41. Although the hydrophobicity of the drugs has most influence on the drug release rate, ion‐pairing may occur between salicylic acid and the basic drugs, chlorhexidine and clindamycin.…”

Section: Resultsmentioning

confidence: 99%

Concurrent release of admixed antimicrobials and salicylic acid from salicylate‐based poly(anhydride‐esters)

Johnson

Uhrich

2008

J Biomedical Materials Res

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A polymer blend consisting of antimicrobials (chlorhexidine, clindamycin, and minocycline) physically admixed at 10% by weight into a salicylic acid-based poly (anhydride-ester) (SA-based PAE) was developed as an adjunct treatment for periodontal disease. The SA-based PAE/ antimicrobial blends were characterized by multiple methods, including contact angle measurements and differential scanning calorimetry. Static contact angle measurements showed no significant differences in hydrophobicity between the polymer and antimicrobial matrix surfaces. Notable decreases in the polymer glass transition temperature (T g ) and the antimicrobials' melting points (T m ) were observed indicating that the antimicrobials act as plasticizers within the polymer matrix. In vitro drug release of salicylic acid from the polymer matrix and for each physically admixed antimicrobial was concurrently monitored by high pressure liquid chromatography during the course of polymer degradation and erosion. Although the polymer/antimicrobial blends were immiscible, the initial 24 h of drug release correlated to the erosion profiles. The SA-based PAE/antimicrobial blends are being investigated as an improvement on current localized drug therapies used to treat periodontal disease.

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Section: Resultsmentioning

confidence: 99%

Concurrent release of admixed antimicrobials and salicylic acid from salicylate‐based poly(anhydride‐esters)

Johnson

Uhrich

2008

J Biomedical Materials Res

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“…Depending on the chemical structure of a molecule and the surface structure of an activated carbon, a molecule may interact with the basal carbon planes (nonspecific interaction),6,7 with a particular polar functional group on the surface (specific interaction),8,9 or with both 6,7. Phenobarbital (Fig.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Surface Lactone Hydrolysis and Temperature on the Specific and Nonspecific Interactions Between Phenobarbital and Activated Carbon Surfaces

Wurster

Aburub

2006

Journal of Pharmaceutical Sciences

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“…The surfaces of activated carbons are heterogeneous, being composed of both hydrophobic regions (bare carbon surface) and a variety of polar functional groups. The latter consist mainly of oxygen-containing functionalities. , Different mechanisms have been found to be involved in adsorption by activated carbons, including van der Waals forces, hydrogen bonding, − electrostatic interactions, ion-pairing and ion exchange, , and hydrophobic bonding. − Many drugs possess both hydrophilic and hydrophobic moieties. The polar parts of the molecule tend to interact with the surface polar functional groups via hydrogen bonding, the Keesom force, the Debye force, or ion−ion interactions, all of which are enthalpy-driven processes .…”

Section: Introductionmentioning

confidence: 99%

“…8,9 Different mechanisms have been found to be involved in adsorption by activated carbons, including van der Waals forces, hydrogen bonding, [10][11][12] electrostatic interactions, ion-pairing and ion exchange, 13,14 and hydrophobic bonding. [15][16][17][18][19][20] Many drugs possess both hydrophilic and hydrophobic moieties. The polar parts of the molecule tend to interact with the surface polar functional groups via hydrogen bonding, the Keesom force, the Debye force, or ion-ion interactions, all of which are enthalpy-driven processes.…”

Section: Introductionmentioning

confidence: 99%

Modified Langmuir-like Model for Modeling the Adsorption from Aqueous Solutions by Activated Carbons

et al. 2004

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A new equation, a modified Langmuir-like equation (M-LLE), for describing adsorption from solution by activated carbons is proposed for the first time in this work. The M-LLE assumes that there are two types of interactions: (a) specific interactions which are typical, enthalpy-driven interactions and (b) nonspecific interactions driven by the loss of water structuring, upon adsorption (hydrophobic bonding), around the nonpolar parts of the drug. The proposed model was evaluated by studying the adsorption of three drugs: procaine, fluoxetine, and phenobarbital by four different activated carbons under different experimental conditions. As the hydrophobicity of the drug increased, the capacity constant representing the interactions driven by hydrophobic bonding (K(HB), M-LLE equation) increased. Experimental conditions that decrease hydrophobic bonding, such as increased temperature and higher cosolvent concentration, resulted in a decrease in K(HB). Salts that tend to increase water structuring and hydrophobic bonding caused an increase in K(HB). All of these studies support the M-LLE, because they support the notion of hydrophobic-bonding-driven interactions.

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Studies on adsorption characteristics and mechanism of adsorption of chlorhexidine mainly by carbon black

Cited by 13 publications

References 24 publications

Concurrent release of admixed antimicrobials and salicylic acid from salicylate‐based poly(anhydride‐esters)

Concurrent release of admixed antimicrobials and salicylic acid from salicylate‐based poly(anhydride‐esters)

The Effects of Surface Lactone Hydrolysis and Temperature on the Specific and Nonspecific Interactions Between Phenobarbital and Activated Carbon Surfaces

Modified Langmuir-like Model for Modeling the Adsorption from Aqueous Solutions by Activated Carbons

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