Studies on a Paratyphoid Infection in Guinea Pigs

Nelson, John B.; Smith, Theobald

doi:10.1084/jem.45.2.353

Cited by 11 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In enzootic salmonellosis of animals including guinea pigs, it is generally regarded that some of infected animals remain for long time as chronic carriers without overt signs of disease [12,17,19,20].…”

Section: Discussionmentioning

confidence: 99%

Epizootiological Studies of <I>Salmonella typhimurium</I> Infection in Guinea Pigs

Iijima

Saito

Nakayama

et al. 1987

Experimental Animals

View full text Add to dashboard Cite

In two natural outbreaks of S. typhimurium infection in guinea pigs, frequent isolations of the organism from the conjunctiva and cervical lymph nodes and high incidences of the conjunctivitis and abscess formation in the cervical lymph nodes were shown, suggesting more importance of the conjunctiva as infection route than oral route. These features in salmonellosis of guinea pigs were tried to reproduce in experimental infections by conjunctival and oral inoculations of 102 and 106 cells of 4 different strains of S. typhimurium and also by contact infection simulating natural conditions. As the results, it was demonstrated that guinea pigs were more susceptible to the conjunctival infection than the oral infection, because higher infection rates and more frequent incidence of abscess formation in the cervical lymph nodes as well as conjunctivitis were produced by the conjunctival inoculation than the oral inoculation of the organism. Main localization sites of the organism were the cervical lymph nodes, conjunctiva and upper respiratory tract in conjunctivally inoculated guinea pigs but more widely distributed in orally infected ones. These findings were common in animals infected with 4 different strains of S. typhimurium and also in contact infection.Thus the conjunctiva was regarded as an important route of S. typhimurium in guinea pigs.

show abstract

Section: Discussionmentioning

confidence: 99%

Epizootiological Studies of <I>Salmonella typhimurium</I> Infection in Guinea Pigs

Iijima

Saito

Nakayama

et al. 1987

Experimental Animals

View full text Add to dashboard Cite

show abstract

“…(Received for publication, July 5, 1928. ) The course of two Salmonella infections appearing spontaneously in a guinea pig population has been discussed in previous papers (1,2). As noted earlier, the guinea pigs comprising the particular population are divided into two groups, breeders and weaned young or stock.…”

mentioning

confidence: 96%

Studies on a Paratyphoid Infection in Guinea Pigs

Nelson

1928

Journal of Experimental Medicine

Self Cite

View full text Add to dashboard Cite

The appearance of a second type of Salmonella in a guinea pig population during the endemic stage of a spontaneous outbreak of paratyphoid disease was reportedin an earlier paper (1). The earliest eases of the first infection occurred in the summer of 1924. The associated organism became rapidly disseminated throughout the population; particularly through the breeding stock, and for a period of 8 weeks a moderately high specific death rate ensued. The epidemic subsequently declined to an endemic level which has persisted up to the present. The course of the infection was followed b y a bacteriological examination of all animals that died in the population under observation.During July and August, 1926, several strains of a second type of Salmonella were isolated from fatal cases. Subsequently there was a slow but general spread of the second organism. These natural occurrences, among the guinea pigs, afforded an opportunity for studying the course of a second infection in an animal population which had been exposed for a considerable period of time to a related but serologically distinct type of organism.A somewhat similar condition in a mouse population was described by Lynch (2). A spontaneous outbreak of paratyphoid infection, of 2 years duration, was followed by a second outbreak caused by a serologically different type of Salmonella. The two types of organism were designated Mouse Typhoid I and 11. Some 18 months prior to the second outbreak half of the population was vaccinated with a strain of Mouse Typhoid I. The specific death rate for the 2O7 on May 9, 2018 jem.rupress.org Downloaded from

show abstract

“…Two organisms were used at the outset to determine whether or not the fly filtrate just described contained substances which were either bactericidal or capable of inhibiting bacterial growth. One of these was a non-mucoid strain of B. coli 223 of calf origin (7), and the other B. paratyphi Type I of guinea pig origin (8).…”

mentioning

confidence: 99%

Bacteriophage Isolated From the Common House Fly (Musca Domestica)

Shope

1927

Journal of Experimental Medicine

View full text Add to dashboard Cite

1. Bacteriophage active against four species of bacteria was found in a salt solution extract of house flies. 2. A growth-inhibiting principle, not bacteriophage, active against four other species of bacteria was found to be present in the same extract. 3. An attempt to secure streptococcus bacteriophage by feeding to flies a streptococcus susceptible to the inhibitor but not to the bacteriophage of this filtrate was unsuccessful, indicating that the two activities are quite unrelated.

show abstract

Studies on a Paratyphoid Infection in Guinea Pigs

Abstract: The course of a natural outbreak of paratyphoid in a normal guinea pig population is outlined. A description is given of the gross pathology of the disease. The bacteriology of the causal organism is discussed with particular reference to its agglutinative affinities.

Cited by 11 publications

References 1 publication

Epizootiological Studies of <I>Salmonella typhimurium</I> Infection in Guinea Pigs

Epizootiological Studies of <I>Salmonella typhimurium</I> Infection in Guinea Pigs

Studies on a Paratyphoid Infection in Guinea Pigs

Bacteriophage Isolated From the Common House Fly (Musca Domestica)

Contact Info

Product

Resources

About