Studies on a feminizing ovarian mesenchymoma (granulosa cell tumor). I. Aspiration biopsy cytology, histology, and ultrastructure

Abstract

A granulosa cell tumor in a 69‐year‐old woman was diagnosed by aspiration biopsy cytology, and different regions were further studied by light and electron microscopy. An almost continuous series of structures, from areas closely imitating normal ovarian follicles and follicular granulosa cells, to minor regions with theca‐like elements was found. The histogenesis, fine structure, and endocrine activity of steroid producing ovarian tumors was discussed, and it was concluded that feminizing or virilizing ovarian mesenchymoma is a suitable collective term for these tumors.

Skeletal metastases from a granulosa-cell tumor of the ovary: Report of a case diagnosed by fine-needle aspiration cytology

“…5 Bjersing et al reported the first case of ovarian granulosacell tumor diagnosed by fine-needle aspiration cytology. 6 The first case of recurrent granulosa cell tumor diagnosed by aspiration cytology was reported by Fidler in 1981 in a 66-yr-old woman. 7 Margolin et al documented the aspiration cytology findings of metastatic granulosa-cell tumor to liver in a 68-yr-old woman.…”

Amenorrhoea and Failure to Virilize in a Patient With a Testosterone Secreting Granulosa Cell Tumour

“…The electron microscopic study indicates that the neoplastic granulosa cells lack smooth endoplasmic reticulum and mitochondria with tubular cristae. They are ultrastructurally identical to both oestrogen-secreting granulosa cell tumours and normal granulosa cells of humans and other mammals (Christensen & Gillim, 1969;Bjersing et al, 1973). They presented the common features of protein secreting tissues.…”

Feminizing adrenocortical carcinoma in a postmenopausal woman

“…When this procedure yields an endometrial hyperplasia with high oestrogenic activity, hormonal determinations must be carried out to exclude the presence of feminizing ovarian or adrenal tumours or a gonadotrophin-producing tumour (Bjersing, Frankendal and Angstrom, 1973). Details of feminizing adrenal tumours with high levels of chorioniclike gonadotrophin hormone in males have been published (Rose et al, 1968).…”