Studies on a bioerodible drug carrier system based on a polyphosphazene

Biomedical applications of degradable polyphosphazenes

“…Poly[(di-ethylglycinate)phosphazene] (Grolleman et al, 1986a(Grolleman et al, , 1986b as well as imidazolyl-substituted polyphosphazenes (Allcock and Fuller, 1981;Laurencin et al, 1987) have been tested as controlled release agents for a number of drugs, including proteins.…”

Synthesis and characterization of novel polyorganophosphazenes substituted with 4-methoxybenzylamine and 4-methoxyphenethylamine for in vitro release of indomethacin and 5-fluorouracil

“…Polyorganophosphazenes (POPs) are novel type of polymers having great potential in biomedical and pharmaceutical applications [1,2]. These polymers are quite well known and are the most widely studied inorganic functional polymers containing nitrogen and phosphorus atoms with a variety of organic substitutents attached to phosphorus.…”

Review : Biodegradation of Drug-Modified Polymers in Drug Delivery- A Critical Analysis

“…In a later paper, Grolleman et al [69] presented identical results for degradable poly(organophosphazene) conjugates, using lysine again as the spacer group between the polymer backbone and Naproxen as the drug. The conjugate molecular weights were defined as Mn = 1-2 x 10' and Mn = > 2 x 10'.…”