Studies of V(III) complexes with selected α-N-heterocyclic carboxylato NO donor ligands: structure of a new seven-coordinated pentagonal bipyramidal complex containing picolinato ligands

Chatterjee, Mainak; Maji, Milan; Ghosh, Saktiprosad; Mak, Thomas C. W.

doi:10.1039/a804160a

Cited by 73 publications

(42 citation statements)

References 37 publications

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“…The synthesis of H[V III (dipic-Cl) 2 ] Á 5H 2 O (V 3 dipic-Cl) was modified from the preparation of a similar complex (Chatterjee et al 1998). First 2.56 g (12.7 mmol) of H 2 dipic-Cl was dissolved in 200 ml of deionized water.…”

Section: Synthesis Of Compoundsmentioning

confidence: 99%

Anti-diabetic effects of vanadium(III, IV, V)–chlorodipicolinate complexes in streptozotocin-induced diabetic rats

Ding

Smee

et al. 2009

Biometals

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Vanadium(III, IV, V)-chlorodipicolinate (dipic-Cl) complexes, including H[VIII(dipic-Cl)2] · 5H2O (V3dipic-Cl), VIVO(dipic-Cl)(H2O)2 (V4dipic-Cl) and K[VVO2(dipic-Cl)] (V5dipic-Cl), were prepared with the indicated oxidation states. Our aim was to evaluate the anti-diabetic effects of V3dipic-Cl, V4dipic-Cl and V5dipic-Cl in streptozotocin-induced diabetic rats. Vanadium complexes were orally administered to diabetic rats at concentrations of 0.1-0.3 mg/ml in the drinking water. We found that vanadium-chlorodipicolinate (V-dipic-Cl) complexes at the concentration of 0.1 mg/ml did not exhibit blood glucose-lowering effects when administered to diabetic rats for 20 days. However, the levels of fasting blood glucose in diabetic rats were decreased after treatment with 0.3 mg/ml of V4dipic-Cl and V5dipic-Cl complexes for the following 20 days. Although administration of both V4dipic-Cl and V5dipic-Cl significantly lowered diabetic hyperglycemia, the vanadium intake from administration of V4dipic-Cl is nearly 1.5-fold greater compared to that of V5dipic-Cl. Treatment with the H2dipic-Cl ligand and all three V-dipic-Cl complexes significantly lowered serum cholesterol, while administration of the V5dipic-Cl complex lowered serum cholesterol significantly more than administration of the ligand alone. Treatment with ligand alone did not have an effect on serum triglyceride, while administration of the V4dipic-Cl and V5dipic-Cl significantly lowered the elevated serum triglyceride associated with diabetes. Oral administration of the ligand and all V-dipic-Cl complexes did significantly lower diabetes elevated serum alkaline phosphatase. Treatment with H2dipic-Cl ligand and V4dipic-Cl and V5dipicCl significantly lowered diabetes elevated aspartate amino transferase. These results indicate that the health of the treated animals did not seem to be further compromised compared to that of diabetic animals. In addition, oral administration of H2dipic-Cl, V3dipic-Cl, V4dipic-Cl and V5dipic-Cl did not alter diabetic serum creatinine and blood urea nitrogen levels, suggesting no significant side effects of vanadium treatment on renal functions at the dose of 0.3 mg/ml in diabetic rats. The results presented here suggest that the anti-diabetic effects of treatment with V-dipic-Cl complexes were likely associated in part with the oxidation state of vanadium.

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Section: Synthesis Of Compoundsmentioning

confidence: 99%

Anti-diabetic effects of vanadium(III, IV, V)–chlorodipicolinate complexes in streptozotocin-induced diabetic rats

Ding

Smee

et al. 2009

Biometals

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“…The stability was attributed to (i) hard-hard interaction of V(III) with O-N bidentate ligand, (ii) to the uncharged nature of the complex, and (iii) to the extensive delocalization of the d-electrons. As an extension, 2,6-pyridinedicarboxylic acid (dipicolinic acid, dipicH 2 ) was used as a ligand for homo-and heterochelated V(III) complexes [216], all of which presented a reversible V(III)/V(II) couple, followed by a second, from quasi-reversible to irreversible, ligand reduction. On the anodic side, two irreversible oxidation peaks were found, attributable to successive oxidations to V(IV) and V(V).…”

Section: Dinuclear Compoundsmentioning

confidence: 99%

A journey into the electrochemistry of vanadium compounds

Galloni

Conte

2015

Coordination Chemistry Reviews

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“…This agrees with the observation in the literature of the heptacoordinated complex [V(dipic)(pic) (H 2 O) 2 ].H 2 O, [23] where pic − corresponds to the picolinate ligand, which is coordinated to the vanadium(III) ion by (N, COO-) and forms a five-membered chelated ring, similar to the amino acids studied in this work, and it was reported that systems forming five-membered chelated ring tend to be heptacoordinated complexes. [24] The analysis of the data performed in the vanadium ( − is very important at pH > 5.…”

Section: the Ternary Complex [V(cys)(b)(oh)]mentioning

confidence: 94%

Potentiometric studies on the formation equilibria of ternary complexes of vanadium(III) with cysteine and some amino acids

Guerra

Martínez

et al. 2015

Chemical Speciation & Bioavailability

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Studies of V(III) complexes with selected α-N-heterocyclic carboxylato NO donor ligands: structure of a new seven-coordinated pentagonal bipyramidal complex containing picolinato ligands

Cited by 73 publications

References 37 publications

Anti-diabetic effects of vanadium(III, IV, V)–chlorodipicolinate complexes in streptozotocin-induced diabetic rats

Anti-diabetic effects of vanadium(III, IV, V)–chlorodipicolinate complexes in streptozotocin-induced diabetic rats

A journey into the electrochemistry of vanadium compounds

Potentiometric studies on the formation equilibria of ternary complexes of vanadium(III) with cysteine and some amino acids

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